Journal Clubs

Sura Markos discusses the findings from the INVICTUS trial and the implications for anticoagulation strategies in patients with rheumatic atrial fibrillation, particularly in low-resource settings.

Tatyana Storozhenko describes the initial studies that demonstrated that the utility of coronary computed tomography angiography extends beyond diagnosis and prevention into the guidance of coronary interventions.

Andrea Zambrano highlights the study that catalysed the field of reverse cardio-oncology by showing that myocardial infarction promotes breast tumour growth in mice.

Liu and Bursill highlight a landmark study that described the presence of in-stent neoatherosclerosis in bare-metal and drug-eluting stents, which has reshaped the clinical management of coronary artery disease.

Annelise Poss discusses the importance of mouse substrain selection in models of cardiovascular research, highlighting a study that demonstrated the influence of mouse substrain genetic diversity on the phenotypic characteristics of the disease model.

Shafqat Ahmad and Gull Rukh discuss a landmark, twin-based, epidemiological study that highlighted how genetic predisposition and environmental factors interact to influence the risk of coronary heart disease.

Valtteri Muroke discusses the LoDoCo trial, in which treatment with low-dose colchicine was shown to reduce cardiovascular end points in patients with stable coronary artery disease, identifying anti-inflammatory therapy as an effective strategy for the secondary prevention of cardiovascular events.

Jorge Peña Peña highlights the 1888 publication from Santiago Ramón y Cajal that provided the first description of the cardiomyocyte sarcolemma.

Lu Yang and Abha Shrestha revisit the first large-scale trial to investigate the effects of telemonitoring on heart failure outcomes and link the lessons learned from the trial to current digital health strategies and challenges.

Xiao-Dong Zhou and Ming-Hua Zheng discuss how Gerald Reaven’s 1988 Banting Lecture laid the groundwork for what we now call metabolic syndrome and reshaped our understanding of metabolic disease.

Leonardo Martin and Guido De Meyer highlight the study that showed that blocking CD40–CD40L signalling could reduce atherosclerosis in mice in vivo.

Seyed Soheil Saeedi Saravi discusses the seminal study that linked a gut microbial metabolite to atherosclerotic cardiovascular disease and opened the way to mechanistic studies assessing how the gut microbiota influences host cardiovascular health.

Jae Hyun Byun and Stella S. Daskalopoulou describe the study that identified lipoprotein(a) as a genetically determined contributor to coronary artery disease.

Mia Manojlovic and Melaku Taye Amogne highlight the 1986 study that unravelled the primary structure of apolipoprotein B100 and laid a foundation for subsequent studies on the role of this apolipoprotein.

Hooi Min Lim describes how the Bogalusa Heart Study emphasized the importance of primordial prevention of cardiovascular disease and profoundly influenced subsequent cardiovascular research on children and adolescents.

Mariella Huaman and Carlos Toro-Huamanchumo discuss the 2013 study that provided crucial insights into the cardiac structural changes associated with obesity and challenged previously established paradigms.

Elizabeth Figueroa-Juárez describes the study that demonstrated that fibroblasts derived from endothelial cells through endothelial-to-mesenchymal transition contribute to cardiac fibrosis.

Anju Loveridge discusses the Framingham Heart Study report that described the link between diabetes mellitus and cardiovascular disease as well as sex-related differences in cardiovascular disease.

Sasha Forbes discusses the study that demonstrated that the electrical activity of the heart could be regulated with light with the use of optogenetics.

Joseph Carr highlights the study that described the rapid component of the delayed-rectifier potassium current and laid the groundwork for later studies into the fundamental biophysics of ion channels.