A group from Technion, Israel, presents data to support an association between diabetic complications and the pattern of inheritance of alleles for the hemoglobin-binding protein haptoglobin. Experimental and preliminary clinical evidence indicate that the antioxidant protection conferred by haptoglobin is dependent upon genotype. Confirmation of the hypothesis will provide the rationale for trials of genotype-guided antioxidant therapies in diabetic populations.
- Farid M Nakhoul
- Rachel Miller-Lotan
- Andrew P Levy
