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Showing 1–17 of 17 results
Advanced filters: Author: A. Kepecs Clear advanced filters

  • The authors mapped spontaneous and choice activity across mouse prefrontal cortex. The activity maps aligned with intrinsic connectivity rather than anatomical subregions, suggesting that connectivity, not cytoarchitecture, organizes prefrontal function.

    • Pierre Le Merre
    • Katharina Heining
    • Marie Carlén
    ResearchOpen Access
    Nature Neuroscience
    P: 1-9

  • Single-cell intracellular recordings have been used as the primary tool for estimating driving forces across inhibitory receptors within the nervous system. Here, the authors present ORCHID as an all-optical method to measure inhibitory receptor driving forces in targeted brain cell types.

    • Joshua S. Selfe
    • Teresa J. S. Steyn
    • Joseph V. Raimondo
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • Traditionally, 'metacognition' has been thought to be the purview of primates, but it is now shown that rats may compute and use estimates of their own confidence when making difficult perceptual decisions. The paper finds correlates of task difficulty and predictors of trial-by-trial outcome in the activity of orbitofrontal cortex, which may be most parsimoniously explained as a representation of subjective confidence.

    • Adam Kepecs
    • Naoshige Uchida
    • Zachary F. Mainen
    Research
    Nature
    Volume: 455, P: 227-231

  • Nature regulars give their recommendations for relaxed, inspiring holiday reading and viewing — from climate-change history to Isaac Newton the detective.

    • David Poeppel
    • Mike Brown
    • Adam Kepecs
    Books & Arts
    Nature
    Volume: 460, P: 574-577

  • The degree of subjective confidence in deciding based on ambiguous sensory cues facilitates learning. Here, the authors report distinct functions of the basolateral amygdala and anterior cingulate cortex on implicit confidence judgements as well as flexible learning under uncertain conditions in rats.

    • A. Stolyarova
    • M. Rakhshan
    • A. Izquierdo
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • The MICrONS mouse visual cortex dataset shows that neurons with similar response properties preferentially connect, a pattern that emerges within and across brain areas and layers, and independently emerges in artificial neural networks where these ‘like-to-like’ connections prove important for task performance.

    • Zhuokun Ding
    • Paul G. Fahey
    • Andreas S. Tolias
    ResearchOpen Access
    Nature
    Volume: 640, P: 459-469

  • Uchida and colleagues consider integration of information for perceptual decision making, focusing on olfactory and visual systems. They argue that there are neural mechanisms that construct discrete sensory samples from a continuous input stream to facilitate important computational functions.

    • Naoshige Uchida
    • Adam Kepecs
    • Zachary F. Mainen
    Reviews
    Nature Reviews Neuroscience
    Volume: 7, P: 485-491

  • How GABAergic interneurons regulate segregation and integration among pyramidal cells to separate brain networks remains unclear. In this study, the authors show that subsets of chandelier cells in prelimbic area mediate directional inhibitory control of both local pyramidal neuron ensembles and global cortical subnetworks.

    • Jiangteng Lu
    • Jason Tucciarone
    • Z Josh Huang
    Research
    Nature Neuroscience
    Volume: 20, P: 1377-1383

  • A deep network is best understood in terms of components used to design it—objective functions, architecture and learning rules—rather than unit-by-unit computation. Richards et al. argue that this inspires fruitful approaches to systems neuroscience.

    • Blake A. Richards
    • Timothy P. Lillicrap
    • Konrad P. Kording
    Reviews
    Nature Neuroscience
    Volume: 22, P: 1761-1770