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Showing 1–14 of 14 results
Advanced filters: Author: A. Stephen K. Hashmi Clear advanced filters

  • Gold redox catalysis has remained challenging owing to the high redox potential of the Au(I)/Au(III) couple (E° = 1.41 V). Now this challenge has been resolved by employing bidentate N-ligands with Au(I) catalysts in combination with hydrogen peroxide as a green and cost-effective oxidant.

    • Sandip A. Bhadange
    • Nitin T. Patil
    News & Views
    Nature Chemistry
    Volume: 17, P: 784-785

  • Direct meta-selective C–H functionalization of pyridines is of paramount importance, but such reactions remain limited and highly challenging. Here, the authors report an electrochemical methodology in which nucleophilic sulfinates allow meta-sulfonylation of pyridines through a redox-neutral dearomatization-rearomatization strategy.

    • Shi Qin
    • Mingkai Yang
    • Zhongyi Zeng
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-8

  • Benzofurazan, a cyclic heterocycle, can form open-chain metal carbene species in the presence of suitable catalysts. Here the authors show divergent reactivity when using gold(III) and platinum(II) catalysts, and perform computational and experimental mechanistic studies to explain the differing reactivity

    • Hongming Jin
    • Wen-Yan Tong
    • A. Stephen K. Hashmi
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-11

  • Gold redox catalysis is an attractive synthetic method but challenging due to the high redox potential of Au(I)/Au(III). Now, a bidentate N-ligand-assisted gold redox catalysis using H2O2 as oxidant has been developed. It can be applied to various coupling reactions, including C(sp)–C(sp) cross-coupling, alkynylative cyclization and bicyclization coupling.

    • Hongwei Shi
    • Matthias Rudolph
    • A. Stephen K. Hashmi
    Research
    Nature Chemistry
    Volume: 17, P: 822-834

  • Syntheses of anilines occur through a variety of methods, most requiring transition metals or multiple steps. Here the authors disclose a protocol to form anilines from benzyl alcohols via an aza-Hock rearrangement that uses only a sulfonyl hydroxylamine and solvent.

    • Tao Wang
    • Philipp M. Stein
    • A. Stephen K. Hashmi
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • Metal carbene is usually employed as a 1-carbon synthon or 3-carbon synthon in a variety of cycloaddition reactions. Here, the authors report a gold-catalyzed cascade protocol for the assembly of polycarbocyclic frameworks via a β-aryl gold-carbene intermediate which reacts as a 4-carbon synthon with alkenes in [4 + 2]-cycloadditions.

    • Cheng Zhang
    • Kemiao Hong
    • Xinfang Xu
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • Gold is the current star of metal catalysis, but most gold catalysts cannot control which mirror-image version of a molecule forms during a reaction. The answer lies with the positive catalyst's negative counter-ion.

    • A. Stephen K. Hashmi
    News & Views
    Nature
    Volume: 449, P: 292-293

  • Intermolecular cyclization reactions using nitrogen-containing building blocks are scarce. Now, bifunctional sulfilimines have been shown to enable the modular construction of a diverse range of N-heterocycles by reacting with alkenes in a single photocatalysed step. Both sulfilimines and alkenes are easily accessible, providing access to a wide range of N-heterocycles with different ring types, ring sizes and substituents on the skeleton.

    • Qiang Cheng
    • Zibo Bai
    • Tobias Ritter
    ResearchOpen Access
    Nature Chemistry
    Volume: 14, P: 898-904

  • Autism is a highly heritable neurodevelopmental disorder, and yet few specific susceptibility genes have been identified to date. A linkage and association mapping study using half a million genome-wide single nucleotide polymorphisms is now described in a common set of 1,031 multiplex autism families. The linkage regions identified provide targets for rare variation screening whereas the discovery of a single novel association, SEMA5A, demonstrates the action of common variants.

    • Lauren A. Weiss
    • Dan E. Arking
    • Leena Peltonen
    Research
    Nature
    Volume: 461, P: 802-808