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Andrew V. Schally obituary: Nobel prizewinner who transformed cancer therapies with research into brain hormones

Endocrinologist whose insight into how the brain controls the endocrine system shaped our understanding of bodily functions.

Renzi Cai
Medhi Wangpaichitr
Comments & Opinion06 Dec 2024
Nature

Volume: 636, P: 567
Characterization of the Hormonal Responses to Luteinizing Hormone-Releasing Hormone (LH-RH) in Prepubertal and Adult Subjects

Abba J Kastin
Andrew V Schally
Enrique Perez-Pasten
Research01 May 1972
Pediatric Research

Volume: 6, P: 481-486
Autoregulation of Release of Melanocyte Stimulating Hormone from the Rat Pituitary

ABBA J. KASTIN
ANDREW V. SCHALLY
Research25 Mar 1967
Nature

Volume: 213, P: 1238-1240
Potent prolactin and growth hormone releasing activity of more analogues of Met-enkephalin

LIONEL CUSAN
ANDRE DUPONT
ANDREW V. SCHALLY
Research11 Aug 1977
Nature

Volume: 268, P: 544-547
Effects of Antibodies to Luteinizing Hormone–Releasing Hormone in the Male Rabbit and on the Rat Oestrous Cycle

HAMISH M. FRASER
ANDREW GUNN
Research20 Jul 1973
Nature

Volume: 244, P: 160-161
Melanocyte-stimulating Hormone Activity of Synthetic MSH and ACTH Peptides, in vivo and in vitro

ABBA J. KASTIN
ANDREW V. SCHALLY
KAZUO KUBO
Research28 Aug 1965
Nature

Volume: 207, P: 978-979
Antagonists of growth-hormone-releasing hormone: an emerging new therapy for cancer

Growth-hormone-releasing hormone (GHRH) and its receptors are expressed in a wide variety of normal and malignant tissues. This article describes various GHRH antagonists, their mechanisms of action, andin vivostudies. These antagonists are a promising potential therapy for a wide range of cancers, and perhaps other diseases.

Andrew V Schally
Jozsef L Varga
Jörg B Engel
Reviews01 Jan 2008
Nature Clinical Practice Endocrinology & Metabolism

Volume: 4, P: 33-43
191 PLASMA LEVELS OF D-TRP-6-LH-RH (DECAPEPTYL) AFTER INTRAMUSCULAR INJECTION OF LONG-ACTING MICROCAPSULES IN CHILDREN TREATED FOR PRECOCIOUS PUBERTY (PP)

Najiba Lahlou
Marc Roger
Andrew V Schally
Research01 Jun 1985
Pediatric Research

Volume: 19, P: 635
Author Correction: Growth hormone-releasing hormone and its analogues in health and disease

Riccarda Granata
Sheila Leone
Andrew V. Schally
Amendments and Corrections28 Nov 2024
Nature Reviews Endocrinology

Volume: 21, P: 196
Publisher Correction: Growth hormone-releasing hormone and its analogues in health and disease

Riccarda Granata
Sheila Leone
Andrew V. Schally
Amendments and Corrections16 Dec 2024
Nature Reviews Endocrinology

Volume: 21, P: 196
Knocking down gene expression for growth hormone-releasing hormone inhibits proliferation of human cancer cell lines

N Barabutis
A V Schally
ResearchOpen Access27 May 2008
British Journal of Cancer

Volume: 98, P: 1790-1796
Protective effects of growth hormone-releasing hormone analogs in DSS-induced colitis in mice

Lucia Recinella
Annalisa Chiavaroli
Sheila Leone
ResearchOpen Access28 Jan 2021
Scientific Reports

Volume: 11, P: 1-14
Drug Insight: clinical use of agonists and antagonists of luteinizing-hormone-releasing hormone

Both agonists and antagonists of luteinizing-hormone-releasing hormone (LHRH) are in clinical use for a wide range of cancers, benign prostatic hypertrophy, fibroids and reproductive disorders. This article describes the existing applications, those under investigation, and potential applications for this type of drug to target diseases such as Alzheimer's.

Jörg B Engel
Andrew V Schally
Reviews01 Feb 2007
Nature Clinical Practice Endocrinology & Metabolism

Volume: 3, P: 157-167
Growth hormone-releasing hormone and its analogues in health and disease

Growth hormone-releasing hormone (GHRH) signalling modulation has shown beneficial effects in a wide range of diseases in preclinical research. This Review discusses the progression of research into the effects of GHRH agonist and antagonist treatment in several contexts, including cancer, inflammation, cardiovascular disease and metabolism.

Riccarda Granata
Sheila Leone
Andrew V. Schally
Reviews13 Nov 2024
Nature Reviews Endocrinology

Volume: 21, P: 180-195
A 50-year journey in the development of treatment for benign prostatic hyperplasia

Andrew V. Schally
George Theodoropoulos
Medhi Wangpaichitr
ReviewsOpen Access23 May 2025
npj Aging

Volume: 11, P: 1-13
Growth hormone releasing hormone signaling promotes Th17 cell differentiation and autoimmune inflammation

Endocrine factors have been shown to alter functions of pathogenic Th17 cells that are involved in autoimmunity. Here the authors study the influence of growth hormone releasing hormone receptor and show that this receptor is found on Th17 cells and promotes ocular autoimmunity.

Lin Du
Bo Man Ho
Wai Kit Chu
ResearchOpen Access06 Jun 2023
Nature Communications

Volume: 14, P: 1-15
Antinflammatory, antioxidant, and behavioral effects induced by administration of growth hormone-releasing hormone analogs in mice

Lucia Recinella
Annalisa Chiavaroli
Sheila Leone
ResearchOpen Access20 Jan 2020
Scientific Reports

Volume: 10, P: 1-14
Anti-inflammatory effects of α-MSH through p-CREB expression in sarcoidosis like granuloma model

Chongxu Zhang
Stephanie Chery
Mehdi Mirsaeidi
ResearchOpen Access29 Apr 2020
Scientific Reports

Volume: 10, P: 1-12
Effects of growth hormone-releasing hormone receptor antagonist MIA-602 in mice with emotional disorders: a potential treatment for PTSD

Lucia Recinella
Annalisa Chiavaroli
Sheila Leone
Research30 Jul 2021
Molecular Psychiatry

Volume: 26, P: 7465-7474
Publisher Correction: Antinflammatory, antioxidant, and behavioral effects induced by administration of growth hormone-releasing hormone analogs in mice

Lucia Recinella
Annalisa Chiavaroli
Sheila Leone
Amendments and CorrectionsOpen Access11 Mar 2020
Scientific Reports

Volume: 10, P: 1
Extracorporeal apheresis therapy for Alzheimer disease—targeting lipids, stress, and inflammation

Stefan R. Bornstein
Karin Voit-Bak
Richard Straube
Reviews08 Oct 2019
Molecular Psychiatry

Volume: 25, P: 275-282

Search

Andrew V. Schally obituary: Nobel prizewinner who transformed cancer therapies with research into brain hormones

Characterization of the Hormonal Responses to Luteinizing Hormone-Releasing Hormone (LH-RH) in Prepubertal and Adult Subjects

Autoregulation of Release of Melanocyte Stimulating Hormone from the Rat Pituitary

Potent prolactin and growth hormone releasing activity of more analogues of Met-enkephalin

Effects of Antibodies to Luteinizing Hormone–Releasing Hormone in the Male Rabbit and on the Rat Oestrous Cycle

Melanocyte-stimulating Hormone Activity of Synthetic MSH and ACTH Peptides, in vivo and in vitro

Antagonists of growth-hormone-releasing hormone: an emerging new therapy for cancer

191 PLASMA LEVELS OF D-TRP-6-LH-RH (DECAPEPTYL) AFTER INTRAMUSCULAR INJECTION OF LONG-ACTING MICROCAPSULES IN CHILDREN TREATED FOR PRECOCIOUS PUBERTY (PP)

Author Correction: Growth hormone-releasing hormone and its analogues in health and disease

Publisher Correction: Growth hormone-releasing hormone and its analogues in health and disease

Knocking down gene expression for growth hormone-releasing hormone inhibits proliferation of human cancer cell lines

Protective effects of growth hormone-releasing hormone analogs in DSS-induced colitis in mice

Drug Insight: clinical use of agonists and antagonists of luteinizing-hormone-releasing hormone

Growth hormone-releasing hormone and its analogues in health and disease

A 50-year journey in the development of treatment for benign prostatic hyperplasia

Growth hormone releasing hormone signaling promotes Th17 cell differentiation and autoimmune inflammation

Antinflammatory, antioxidant, and behavioral effects induced by administration of growth hormone-releasing hormone analogs in mice

Anti-inflammatory effects of α-MSH through p-CREB expression in sarcoidosis like granuloma model

Effects of growth hormone-releasing hormone receptor antagonist MIA-602 in mice with emotional disorders: a potential treatment for PTSD

Publisher Correction: Antinflammatory, antioxidant, and behavioral effects induced by administration of growth hormone-releasing hormone analogs in mice

Extracorporeal apheresis therapy for Alzheimer disease—targeting lipids, stress, and inflammation

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