Biochemist at Technion, the Israeli Institute of Technology in Haifa. Shared the 2004 Nobel Prize in Chemistry for the discovery of the ubiquitin system, which mediates protein degradation in all plant and animal cells by destroying proteins that are denatured, misfolded or no longer needed. Family moved from Poland in the 1920s, and he was born in Haifa in 1947. The following year the state of Israel was established.