In this manuscript, the authors develop a computational framework to design protein peptide interactions, and they use the method to identify peptides that bind to human bZIP transcription factors. Despite that fact that bZIP proteins share strong sequence and structural similarities, the authors were able to find peptides that selectively bound to one family, but not the 19 other families.
- Gevorg Grigoryan
- Aaron W. Reinke
- Amy E. Keating
