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Nature Nanotechnology (1)

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A disease-severity-responsive nanoparticle enables potent ghrelin messenger RNA therapy in osteoarthritis

Nanoparticles sensing glycosaminoglycan loss in osteoarthritis enable disease-severity-responsive delivery of ghrelin messenger RNA to cartilage lesions, reducing cartilage damage, bone thickening and pain in animal models.

Mahima Dewani
Anjali Rajesh Mamidwar
Li Zeng
Research14 Jan 2026
Nature Nanotechnology

P: 1-12

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A disease-severity-responsive nanoparticle enables potent ghrelin messenger RNA therapy in osteoarthritis

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