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Showing 1–7 of 7 results
Advanced filters: Author: Abhi Aggarwal Clear advanced filters

  • iGluSnFR4f and iGluSnFR4s are the latest generation of genetically encoded glutamate sensors. They are advantageous for detecting rapid dynamics and large population activity, respectively, as demonstrated in a variety of applications in the mouse brain.

    • Abhi Aggarwal
    • Adrian Negrean
    • Kaspar Podgorski
    ResearchOpen Access
    Nature Methods
    P: 1-9

  • Genetically-encoded indicators with more red-shifted excitation and emission wavelengths are advantageous for in vivo imaging. Here, Dalangin et al. report the engineering of far-red fluorescent Ca2+ indicators and demonstrate their utility for monitoring of all-optical cardiac pacing in embryonic zebrafish.

    • Rochelin Dalangin
    • Bill Z. Jia
    • Robert E. Campbell
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • l-Lactate is increasingly recognized as a key metabolite and signalling molecule in mammals, but the methods to investigate it in vivo have been limited. Here, authors report a pair of improved biosensors—one green and one red—for visualizing l-lactate both inside and outside of cells.

    • Yusuke Nasu
    • Abhi Aggarwal
    • Robert E. Campbell
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • l-lactate is an important intercellular energy currency. Here the authors report a genetically encoded biosensor eLACCO1.1 to monitor extracellular l-lactate; they use eLACCO1.1 to image extracellular l-lactate in cultured mammalian cells and brain tissue.

    • Yusuke Nasu
    • Ciaran Murphy-Royal
    • Robert E. Campbell
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • Yi Shen et al. report two classes of genetically encoded fluorescent potassium indicators, based on FRET (KIRIN1 and KIRIN1-GR) or single-wavelength fluorescence change (GINKO1). These K+ indicators enable imaging of intracellular K+ dynamics in live cells with a multiplexing potential.

    • Yi Shen
    • Sheng-Yi Wu
    • Min Dong
    ResearchOpen Access
    Communications Biology
    Volume: 2, P: 1-10