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Showing 1–3 of 3 results
Advanced filters: Author: Abhijith Radhakrishnan Clear advanced filters

  • The presynaptic protein Munc13 forms nanoclusters at synaptic release sites, but its internal organization is unclear. Here, the authors show that two distinct ordered Munc13 oligomers couple synaptic vesicle docking and SNARE assembly to regulate neurotransmission

    • Manindra Bera
    • Kirill Grushin
    • Jeremy S. Dittman
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18

  • AbgT family of transporters have previously been implicated in the uptake of folate catabolites but remain poorly understood. Here the authors present a structural and functional characterization of Alcanivorax borkumensisYdaH, an AbgT-type transporter, revealing a unique topology and possible function as a drug efflux pump.

    • Jani Reddy Bolla
    • Chih-Chia Su
    • Edward W. Yu
    Research
    Nature Communications
    Volume: 6, P: 1-10

  • Multidrug efflux pumps significantly contribute for bacteria resistance to antibiotics. Here the authors present the structure of Campylobacter jejuni CmeB pump combined with functional FRET assays to propose a transport mechanism where each CmeB protomers is functionally independent from the trimer.

    • Chih-Chia Su
    • Linxiang Yin
    • Edward W. Yu
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-11