Nature Search

A benchmark of expert-level academic questions to assess AI capabilities

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Long Phan
Alice Gatti
Davide Scaramuzza
ResearchOpen Access28 Jan 2026
Nature

Volume: 649, P: 1139-1146
Noninvasive biventricular pressure-strain-volume loop-derived myocardial work analysis in competitive athletes

Andrea Ferencz
Ádám Szijártó
Alexandra Fábián
ResearchOpen Access08 Jan 2026
Scientific Reports

P: 1-14
Reversible covalent c-Jun N-terminal kinase inhibitors targeting a specific cysteine by precision-guided Michael-acceptor warheads

Bálint et al utilized cyclohexenone and cyclopentenone based reversible covalent warheads to produce specific composite c-Jun N-terminal kinase inhibitors to demonstrate the modular nature of Michael acceptor based cyclic warhead designs.

Dániel Bálint
Ádám Levente Póti
Attila Reményi
ResearchOpen Access04 Oct 2024
Nature Communications

Volume: 15, P: 1-19
Phylogenetic barriers to horizontal transfer of antimicrobial peptide resistance genes in the human gut microbiota

Antimicrobial peptide resistance genes are found to be widespread in the gut microbiome but are exchanged at lower rates compared to antibiotic resistance genes, with functional compatibility between bacteria being important for gene exchange.

Bálint Kintses
Orsolya Méhi
Csaba Pál
Research17 Dec 2018
Nature Microbiology

Volume: 4, P: 447-458
Chemical-genetic profiling reveals limited cross-resistance between antimicrobial peptides with different modes of action

The genetics underlying bacterial susceptibility to antimicrobial peptides (AMPs) remain unclear. Here, using a genome-wide chemical-genetic approach, the authors map the diversity of resistance determinants across AMPs in Escherichia coli and provide evidence that cross-resistance is prevalent only between AMPs with similar modes of action.

Bálint Kintses
Pramod K. Jangir
Balázs Papp
ResearchOpen Access16 Dec 2019
Nature Communications

Volume: 10, P: 1-13
Antibiotic-resistant bacteria show widespread collateral sensitivity to antimicrobial peptides

Multidrug-resistant Escherichia coli have a high frequency of collateral sensitivity to antimicrobial peptides, which may arise from changes in lipopolysaccharide regulation.

Viktória Lázár
Ana Martins
Csaba Pál
Research24 May 2018
Nature Microbiology

Volume: 3, P: 718-731
Mammal responses to global changes in human activity vary by trophic group and landscape

Analysing camera-trap data of 163 mammal species before and after the onset of COVID-19 lockdowns, the authors show that responses to human activity are dependent on the degree to which the landscape is modified by humans, with carnivores being especially sensitive.

A. Cole Burton
Christopher Beirne
Roland Kays
ResearchOpen Access18 Mar 2024
Nature Ecology & Evolution

Volume: 8, P: 924-935
Atmospheric air plasma pre-activation and customizable covalent functionalization of PVDF-membranes of microtiter filter plates

Bálint Árpád Ádám
Sára Spátay
Ádám Golcs
ResearchOpen Access25 Jan 2025
Scientific Reports

Volume: 15, P: 1-20
Targeting a key protein-protein interaction surface on mitogen-activated protein kinases by a precision-guided warhead scaffold

Póti et al developed cyclic, tuneable and chiral warheads against the protein-protein interaction surface of mitogen-activated protein kinases, which form a reversible covalent bond with nucleophilic surface residues to modulate cellular signaling networks.

Ádám Levente Póti
Dániel Bálint
Attila Reményi
ResearchOpen Access04 Oct 2024
Nature Communications

Volume: 15, P: 1-22
Integrated evolutionary analysis reveals antimicrobial peptides with limited resistance

Antimicrobial peptides (AMPs) are emerging as drug candidates, but the risk of pathogen resistance is not well understood. Here, the authors investigate AMP resistance evolution in E. coli, finding physicochemical features that make AMPs less prone to resistance and no cross- or horizontally-acquired resistance.

Réka Spohn
Lejla Daruka
Csaba Pál
ResearchOpen Access04 Oct 2019
Nature Communications

Volume: 10, P: 1-13
Novel Sigma-1 receptor agonist alleviates renal ischemic injury by targeting apoptotic and inflammatory pathways

Akos R. Toth
Tamas Lakat
Adam Hosszu
ResearchOpen Access13 Nov 2025
Scientific Reports

Volume: 15, P: 1-12
Social and genetic diversity in first farmers of central Europe

Gelabert et al. examine genomic and archaeological data from Europe’s earliest farming communities in Central Europe (5500–5000 bce). They find differentiated genetic networks but no evidence of unequal access to resources linked to sex or kin.

Pere Gelabert
Penny Bickle
David Reich
Research29 Nov 2024
Nature Human Behaviour

Volume: 9, P: 53-64
Sharp-wave ripple doublets induce complex dendritic spikes in parvalbumin interneurons in vivo

The influence of sharp-wave ripples (SPW-Rs) on dendritic computation remains poorly understood. Here, the authors demonstrate the existence of SPW-R associated, branch-specific, dendritic spikes which serve as a temporal and spatial coincidence detectors during SPW-R-doublets in PV+ interneuron dendrites of awake mice.

Linda Judák
Balázs Chiovini
Balázs Rózsa
ResearchOpen Access07 Nov 2022
Nature Communications

Volume: 13, P: 1-15
A structural biology community assessment of AlphaFold2 applications

Here, the authors evaluate the performance of AlphaFold2 and its predicted structures on common structural biological applications, including missense variants, function and ligand binding site prediction, modeling of interactions and modeling of experimental structural data.

Mehmet Akdel
Douglas E. V. Pires
Pedro Beltrao
ResearchOpen Access07 Nov 2022
Nature Structural & Molecular Biology

Volume: 29, P: 1056-1067
Time-crystalline eigenstate order on a quantum processor

A study establishes a scalable approach to engineer and characterize a many-body-localized discrete time crystal phase on a superconducting quantum processor.

Xiao Mi
Matteo Ippoliti
Pedram Roushan
ResearchOpen Access30 Nov 2021
Nature

Volume: 601, P: 531-536
Genome-wide analysis captures the determinants of the antibiotic cross-resistance interaction network

Understanding how evolution of antimicrobial resistance increases resistance to other drugs is of key importance. Here, Lazar et al. build a map of cross-resistance interactions between antibiotics in Escherichia coliand show that chemical and genomic similarities are good predictors of bacterial cross-resistance.

Viktória Lázár
István Nagy
Csaba Pál
ResearchOpen Access08 Jul 2014
Nature Communications

Volume: 5, P: 1-12
The immune synapse clears and excludes molecules above a size threshold

Natural killer cells can be switched on or off by the immune synapse formed with another cell. Here, the authors show that when a natural killer cell is activated, the immune synapse also functions to clear and exclude extracellular molecules, including antibodies, in a size-dependent manner.

Adam N. R. Cartwright
Jeremy Griggs
Daniel M. Davis
ResearchOpen Access19 Nov 2014
Nature Communications

Volume: 5, P: 1-13
Resting-state fMRI data of awake dogs (Canis familiaris) via group-level independent component analysis reveal multiple, spatially distributed resting-state networks

Dóra Szabó
Kálmán Czeibert
Enikő Kubinyi
ResearchOpen Access24 Oct 2019
Scientific Reports

Volume: 9, P: 1-25
Validation of a novel, low-fidelity virtual reality simulator and an artificial intelligence assessment approach for peg transfer laparoscopic training

Peter Zoltan Bogar
Mark Virag
Peter Maroti
ResearchOpen Access19 Jul 2024
Scientific Reports

Volume: 14, P: 1-14
Genetic diversity of PRRSV 1 in Central Eastern Europe in 1994–2014: origin and evolution of the virus in the region

Gyula Balka
Katarzyna Podgórska
Tomasz Stadejek
ResearchOpen Access17 May 2018
Scientific Reports

Volume: 8, P: 1-12
Antibody decay, T cell immunity and breakthrough infections following two SARS-CoV-2 vaccine doses in inflammatory bowel disease patients treated with infliximab and vedolizumab

Vaccination is effective in protecting from COVID-19. Here the authors report immune responses and breakthrough infections in twice-vaccinated patients receiving anti-TNF treatments for inflammatory bowel disease, and find dampened vaccine responses that implicate the need of adapted vaccination schedules for these patients.

Simeng Lin
Nicholas A. Kennedy
Jeannie Bishop
ResearchOpen Access16 Mar 2022
Nature Communications

Volume: 13, P: 1-14
Long-term prognostic value of myocardial work analysis across obesity stages: insights from a community-based study

Fjolla Zhubi Bakija
Máté Tolvaj
Alexandra Fábián
ResearchOpen Access06 Aug 2025
International Journal of Obesity

Volume: 49, P: 2032-2041
Exponential suppression of bit or phase errors with cyclic error correction

Repetition codes running many cycles of quantum error correction achieve exponential suppression of errors with increasing numbers of qubits.

Zijun Chen
Kevin J. Satzinger
Julian Kelly
ResearchOpen Access14 Jul 2021
Nature

Volume: 595, P: 383-387
Nanostructural and nanomechanical alterations of photosensitized lipid membranes due to light induced formation of reactive oxygen species

Ádám Zolcsák
Bálint Kiss
Levente Herenyi
ResearchOpen Access02 Jan 2025
Scientific Reports

Volume: 15, P: 1-13
A dynamic CD2-rich compartment at the outer edge of the immunological synapse boosts and integrates signals

The adhesion receptor CD2 plays an important role in the full activation of T cells. Dustin and colleagues show that CD2 occupies a region in the periphery of the immunological synapse where it amplifies cognate antigen signals, whereas the presence of PD-1 disrupts this effect.

Philippos Demetriou
Enas Abu-Shah
Michael L. Dustin
Research14 Sept 2020
Nature Immunology

Volume: 21, P: 1232-1243
Dogs can sense weak thermal radiation

Anna Bálint
Attila Andics
Ronald H. H. Kröger
ResearchOpen Access28 Feb 2020
Scientific Reports

Volume: 10, P: 1-9
A large multi-focus dataset for white blood cell classification

Seongjin Park
Hyunghun Cho
Kyu-Hwan Jung
ResearchOpen Access09 Oct 2024
Scientific Data

Volume: 11, P: 1-6
Proteome-wide landscape of solubility limits in a bacterial cell

Ádám Györkei
Lejla Daruka
Balázs Papp
ResearchOpen Access21 Apr 2022
Scientific Reports

Volume: 12, P: 1-13
Chronic liver disease is an important risk factor for worse outcomes in acute pancreatitis: a systematic review and meta-analysis

Jakub Hoferica
Ruben Zsolt Borbély
Péter Jenő Hegyi
ResearchOpen Access19 Jul 2024
Scientific Reports

Volume: 14, P: 1-13
Effect of hypercholesterolemia on circulating and cardiomyocyte-derived extracellular vesicles

Csenger Kovácsházi
Szabolcs Hambalkó
Zoltán Giricz
ResearchOpen Access26 May 2024
Scientific Reports

Volume: 14, P: 1-14
Discharge protocol in acute pancreatitis: an international survey and cohort analysis

Rita Nagy
Klementina Ocskay
Péter Hegyi
ResearchOpen Access13 Dec 2023
Scientific Reports

Volume: 13, P: 1-10
Analgesic and Anti-Inflammatory Effects of the Novel Semicarbazide-Sensitive Amine-Oxidase Inhibitor SzV-1287 in Chronic Arthritis Models of the Mouse

Ádám Horváth
Awt Menghis
Zsuzsanna Helyes
ResearchOpen Access09 Jan 2017
Scientific Reports

Volume: 7, P: 1-13
Investigations on spreading of PRRSV among swine herds by improved minimum spanning network analysis

Péter Márton Szabó
Dóra Szalay
Ádám Bálint
ResearchOpen Access05 Nov 2020
Scientific Reports

Volume: 10, P: 1-9
A novel mutation tolerant padlock probe design for multiplexed detection of hypervariable RNA viruses

Sibel Ciftci
Felix Neumann
Mats Nilsson
ResearchOpen Access27 Feb 2019
Scientific Reports

Volume: 9, P: 1-10
Lineage diversification, homo- and heterologous reassortment and recombination shape the evolution of chicken orthoreoviruses

Szilvia L. Farkas
Szilvia Marton
Krisztián Bányai
ResearchOpen Access10 Nov 2016
Scientific Reports

Volume: 6, P: 1-9
Prediction and characterization of human ageing-related proteins by using machine learning

Csaba Kerepesi
Bálint Daróczy
András Benczúr
ResearchOpen Access06 Mar 2018
Scientific Reports

Volume: 8, P: 1-13
Stone–Wales defects in hexagonal boron nitride as ultraviolet emitters

Hanen Hamdi
Gergő Thiering
Adam Gali
ResearchOpen Access27 Nov 2020
npj Computational Materials

Volume: 6, P: 1-7
Sunflower inflorescences absorb maximum light energy if they face east and afternoons are cloudier than mornings

Gábor Horváth
Judit Slíz-Balogh
Imre M. Jánosi
ResearchOpen Access09 Dec 2020
Scientific Reports

Volume: 10, P: 1-15
Therapeutic sensitivity to standard treatments in BRCA positive metastatic castration-resistant prostate cancer patients—a systematic review and meta-analysis

Tamás Fazekas
Ádám D. Széles
Tibor Szarvas
ReviewsOpen Access12 Dec 2022
Prostate Cancer and Prostatic Diseases

Volume: 26, P: 665-672

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