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Showing 1–14 of 14 results
Advanced filters: Author: Adam Griesemer Clear advanced filters

  • Xenotransplantation of a genetically edited pig kidney with a thymic autograft into a brain-dead human for 61 days with immunosuppression resulted in stable kidney function without proteinuria, and xenograft rejection was treated and reversed by the end of the study.

    • Robert A. Montgomery
    • Jeffrey M. Stern
    • Megan Sykes
    Research
    Nature
    Volume: 650, P: 218-229

  • Together with a companion paper, molecular details of immune responses in a pig-to-human xenotransplantation are identified through dense longitudinal multi-omics profiling of the xenograft and the host recipient, across the 61-day procedure.

    • Eloi Schmauch
    • Brian D. Piening
    • Brendan J. Keating
    Research
    Nature
    Volume: 650, P: 205-217

  • In a short-term study in which hearts from gene-edited pigs were transplanted into two recently deceased human recipients, the hearts were able to function for the duration of the study without signs of rejection and without evidence of pig virus transmission, encouraging further clinical study of cardiac xenotransplantation.

    • Nader Moazami
    • Jeffrey M. Stern
    • Robert A. Montgomery
    Research
    Nature Medicine
    Volume: 29, P: 1989-1997

  • Multi-omics profiling of the blood and heart of two human decedents receiving pig heart xenografts, including single-cell studies, reveals early immune responses and perioperative cardiac xenograft dysfunction in one of the two decedents, which may be due to mismatched heart size and/or insufficient immunosuppression.

    • Eloi Schmauch
    • Brian Piening
    • Brendan J. Keating
    Research
    Nature Medicine
    Volume: 30, P: 1448-1460

  • In a new strategy for increasing the availability of lungs for transplantation, human lungs declined for transplantation because of their poor quality can be recuperated by connecting them to the circulation of a pig.

    • Ahmed E. Hozain
    • John D. O’Neill
    • Gordana Vunjak-Novakovic
    Research
    Nature Medicine
    Volume: 26, P: 1102-1113

  • Using kidneys from a genetically engineered porcine donor transplanted into a cynomolgus monkey model, the design, creation and long-term function of kidney grafts supporting life are explored.

    • Ranjith P. Anand
    • Jacob V. Layer
    • Wenning Qin
    ResearchOpen Access
    Nature
    Volume: 622, P: 393-401

  • DEED captures the balance between entropy gains and costs, allowing the correct classification of functional synthesizability of multicomponent ceramics, regardless of chemistry and structure, and provides an array of potential new candidates, ripe for experimental discoveries.

    • Simon Divilov
    • Hagen Eckert
    • Stefano Curtarolo
    ResearchOpen Access
    Nature
    Volume: 625, P: 66-73

  • Pigs offer a potentially plentiful supply of organs for humans, but widespread xenotransplantation will require a collaborative and iterative approach to research, as well as involvement of transplant patients and the public.

    • Robert A. Montgomery
    • Sapna A. Mehta
    • Adam Griesemer
    Comments & Opinion
    Nature Medicine
    Volume: 28, P: 1533-1536

  • Emerging perfusion technologies restore circulation and mitigate cell damage post ischaemia and reperfusion, showing promise for resuscitation medicine and organ transplantation. This Review explores cellular injury mechanisms, machine perfusion approaches and perfusate modifications for organ and whole-body recovery following circulatory cessation.

    • David Andrijevic
    • Ana Spajic
    • Nenad Sestan
    Reviews
    Nature Reviews Bioengineering
    Volume: 3, P: 596-611