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Showing 1–11 of 11 results
Advanced filters: Author: Adam J. Grippin Clear advanced filters

  • Macrophage-dependent phagocytosis elicits robust antitumor immunity. Nevertheless, therapeutic strategies harnessing phagocytosis have been met with limited success. Here the authors demonstrate that dual-phagocytosis checkpoint blockade, achieved by simultaneously targeting CD47 and CD24, greatly enhances tumor cell phagocytosis thus increasing antigen-presentation capacity, cGAS-STING activation and T cell infiltration into the tumor microenvironment, ultimately fostering robust antitumor immunity in preclinical mouse models of glioblastoma.

    • JongHoon Ha
    • Yifan Wang
    • Wen Jiang
    ResearchOpen Access
    Nature Communications
    P: 1-12

  • The limited infiltration and migration of T cells in the brain can hinder the success of immune checkpoint blockade in glioblastoma (GBM). Here the authors show that an adeno-associated virus-based gene therapy for the intratumor delivery of CXCL9 promotes T cell infiltration and enhances response to anti-PD1 in GBM preclinical models.

    • Christina A. von Roemeling
    • Jeet A. Patel
    • Duane A. Mitchell
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-20

  • There is an emerging interest in the use of mRNA therapeutics in cancer treatment, but their precise in vivo delivery remains a challenge. Here the authors develop IFN-γ mRNA-loaded small extracellular vesicles (sEVs) with CD64 overexpressed on their surface and demonstrate its efficacy in glioblastoma mouse models resistant to immunotherapy.

    • Shiyan Dong
    • Xuan Liu
    • Wen Jiang
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • Kim and colleagues provide an overview of the current state of the art of nanomaterials and their application in immuno-oncology, discussing preclinical development and the clinical landscape.

    • Adam J. Grippin
    • DaeYong Lee
    • Betty Y. S. Kim
    Reviews
    Nature Cancer
    Volume: 6, P: 1311-1325

  • Despite advances in active drug-targeting for blood-brain barrier penetration, challenges related to brain biodistribution, and drug accumulation persist. Here the authors show a molecular library design centered on cyclic tertiary amine compounds and develop a self-enhanced brain-targeted nucleic acid delivery system inspired by the neuroprotective properties of vinpocetine.

    • Xufei Bian
    • Ling Yang
    • Chong Li
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • CAR T-cell therapy efficacy in solid tumors is limited by inadequate T-cell migration and/or persistence in tumour microenvironment. Here, the authors show that the activity of tumour-antigen specific CAR T cells, in multiple preclinical mouse models, can be enhanced by co-expression of two IL-8 receptors that mediate their migration into the tumor microenvironment when IL-8 production in tumor is naturally expressed or enhanced by radiation.

    • Linchun Jin
    • Haipeng Tao
    • Jianping Huang
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13