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Showing 1–4 of 4 results
Advanced filters: Author: Adam M. Kresak Clear advanced filters

  • The factors contributing to the onset of Barrett’s esophagus, a precancerous stage of the highly lethal esophageal cancer, remain elusive. Here, the authors identify inherited mutations in the VSIG10L gene as a key etiologic determinant affecting esophageal biology and facilitating the development of Barrett’s esophagus.

    • Durgadevi Ravillah
    • Salendra Singh
    • Kishore Guda
    ResearchOpen Access
    Nature Communications
    P: 1-15

  • Response to chemotherapy in patients with pancreatic ductal adenocarcinoma (PDAC) is often limited. Here, the authors report improved response to chemotherapy in PDAC patients with hyperglycaemia and investigate the underlying mechanism via glucose-mediated disruption of redox metabolism

    • Ali Vaziri-Gohar
    • Jonathan J. Hue
    • Jordan M. Winter
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • CAR T-cell therapy efficacy in solid tumors is limited by inadequate T-cell migration and/or persistence in tumour microenvironment. Here, the authors show that the activity of tumour-antigen specific CAR T cells, in multiple preclinical mouse models, can be enhanced by co-expression of two IL-8 receptors that mediate their migration into the tumor microenvironment when IL-8 production in tumor is naturally expressed or enhanced by radiation.

    • Linchun Jin
    • Haipeng Tao
    • Jianping Huang
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13