Search

Your paper has been accepted, reviewed and published. Now you need to get it talked about by journalists, the public, your peers and funders.

Scientist-turned-lawyer Tamsen Valoir outlines a key step on the road to commercializing your research.

Seasoned science entrepreneurs tell Adam Levy how to take the daunting first steps to commercializing your research.

How to choose a workplace that is welcoming and safe, and where your career will thrive.

Meet the people who advise researcher entrepreneurs on patents, licensing, business plans and commercial partnerships.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Move over silicon: scientists want to use neurons to make powerful computers with minuscule energy needs.

Serological profiles from two observational cohort studies in The Gambia characterize surrogates of protection against Streptococcus pyogenes and reveal an antibody response against antigens that are currently in vaccine development.

Many large drug companies are now taking advantage of the specialist skills offered by smaller biotech firms in their search for new drugs. This trend for outsourcing elements of research is forcing a careful evaluation of licensing policy, says Adam Smith.

In regenerative medicine, stem-cell-derived extracellular vesicles are emerging as cell-free nanotherapeutics. Here, the authors show that coating these nanovesicles with blood proteins such as albumin improves their uptake by liver cells, offering a better treatment strategy for liver diseases.

The treatment potential of psilocybin for postpartum depression was investigated in a preclinical mouse model. Here the authors show both acute and long-term effects of psilocybin in mothers and their offspring who were exposed via lactation.

Complete sequences of chromosomes telomere-to-telomere from chimpanzee, bonobo, gorilla, Bornean orangutan, Sumatran orangutan and siamang provide a comprehensive and valuable resource for future evolutionary comparisons.

Explosives rely on tiny bubbles to bring the house down. David Adam investigates how medical imaging can check their fizz. .

A large international panel of experts reach consensus on a new standard for reporting settings in psychedelic trials, identifying 30 key non-pharmacological factors to strengthen the rigor of psychedelic research.

Abbasi et al. evaluate the value of source data verification, a costly but traditional element of clinical trials. They find it is largely redundant when used with a systematic strategy to promote efficient and accurate data capture, monitoring, and safety in a phase II platform trial.

Trial Registration: https://clinicaltrials.gov/study/NCT04488081

A generation of entrepreneurs is being nurtured to kickstart European biotechnology.

Analysis of sedimentary rocks from the mid-Proterozoic interval reveals traces of protosteroids, suggesting the widespread presence of stem-group eukaryotes that predated and co-existed with the crown-group ancestors of modern eukaryotes.

Ossenkoppele, Coomans and colleagues analyzed the tau PET data of 12,048 individuals from 42 cohorts worldwide. They found that age, amyloid-β status, presence of an APOE ε4 allele and female sex are key contributors to tau PET positivity, which should aid clinical decision-making and trial designs.

Guhathakurta et al. describe the acetyltransferase activity of MOF in the mitochondria. MOF can acetylate COX17, thus contributing to the assembly and function of respiratory complex IV. These findings provide better understanding of how mitochondrial function is fine-tuned by acetylation.

Massive financial endowments allow the top US universities to offer the best salaries and conditions in the academic world. David Adam asks how their British counterparts can close the gap.

Rossjohn, van der Vliet and colleagues develop single-domain antibodies binding composite CD1d and NKT T-cell receptor antigens, inducing specific antitumor immune subsets.

The biotech scene, although volatile, will continue to provide jobs. But potential employees should prepare for a bumpy ride, say Paul Smaglik and Adam Smith.

Researchers who aspire to work in drug discovery need to adapt to constantly changing technology and be able to harness new tools both to ask and to answer pertinent scientific questions, say Paul Smaglik and Adam Smith.

Medical adviser Michael Duncan says rescuing trapped miners is just the first step

The molecular mechanisms underlying tumour initiation remain elusive. Here, the authors use spatiotemporally controlled oncogene activation and tumour suppressor inhibition with multi-omics to unveil the role of YAP-mediated oral epithelial progenitor cell reprogramming into tumour-initiating cells.

Meta’s planned shift away from third-party fact-checking on Facebook in favour of a crowdsourced approach has perplexed those who study the spread of misinformation.

Empirically based models of disease progression in familial frontotemporal dementia reveal the relative ordering of clinical, neuroimaging, and fluid biomarker changes and facilitate novel clinical trial designs

In the final report of a phase 1 trial evaluating intracerebroventricular B7-H3-targeting CAR T cells in children and young adults with diffuse intrinsic pontine glioma, repeated intracranial infusions were feasible and well tolerated with a median overall survival of 19.8 months and 3 patients surviving over 40 months from diagnosis.

Studies of transfers of surplus military equipment to police have argued that they reduce crime. Gunderson et al. reanalysed US federal data and replicated key studies. They find no credible evidence that crime drops when local police get more SME.

Healthspan and healthy aging are areas of research with potential socioeconomic impact. Here, the authors present the Medical Genome Reference Bank (MGRB) which consist of over 4,000 individuals aged 70 years and older without a history of the major age-related diseases and report on results from whole-genome sequencing and association analyses.

Karoutas et al. report lamin A/C as a non-histone target for the acetyltransferase MOF. They find that lamin A/C acetylation prevents nuclear envelope rupture and maintains nuclear integrity.

mRNA medicines hold enormous promise for drugging targets outside the reach of classic small molecules. Here, the authors develop a modular platform to design programmable mRNA therapeutics that act by modifying epigenetic state.

As the 'war on terrorism' unfolds, some politicians are calling for controls on the availability of encryption software. But many computer scientists claim such moves would play into the terrorists' hands. David Adam reports.

Genetic engineering creeps up the evolutionary ladder.

This paper explores legal processes for penalty setting in water theft cases in transboundary water systems and develops ideas to identify differences and potentially drive consistency between jurisdictions.

Fat distribution is associated with cardiometabolic disease, although it has been less well studied than overall obesity. In a multiancestry exome-sequencing study, the authors identified predicted loss-of-function mutations in INHBE associated with favorable fat distribution and protection from type 2 diabetes.

The adhesion receptor CD2 plays an important role in the full activation of T cells. Dustin and colleagues show that CD2 occupies a region in the periphery of the immunological synapse where it amplifies cognate antigen signals, whereas the presence of PD-1 disrupts this effect.

A diverse, multidisciplinary panel of 386 experts in COVID-19 response from 112 countries provides health and social policy actions to address inadequacies in the pandemic response and help to bring this public health threat to an end.