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Showing 1–6 of 6 results
Advanced filters: Author: Adam Shahine Clear advanced filters

  • Despite extensive structural studies elucidating how antigens are anchored to antigen-presenting molecules and presented to T cells, little is known about the display mechanism of the lipid-antigen-presenting molecule CD1c. Here, by combining structural immunology, lipidomics, and biophysical analysis, the authors reveal that the CD1c binding cleft accommodates two different lipids, one of them with a bulky headgroup positioned sideways for display to T cells, rather than upwards, different from the conventional upright antigen-presentation mode

    • Thinh-Phat Cao
    • Guan-Ru Liao
    • Jamie Rossjohn
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-14

  • CD1 proteins present lipid antigens to T cells via the T cell receptor. Here the authors describe T cell reactivity to human membrane lipid moieties and provide structural data to define a molecular mechanism of promiscuous recognition of self-derived phospholipids.

    • Adam Shahine
    • Peter Reinink
    • Ildiko Van Rhijn
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • De Jong and colleagues identify staphylococcal phosphatidylglycerol lipids as antigens for human CD1a-restricted T cells, which promote type 2 immune responses and may contribute to atopic dermatitis.

    • Gwennaëlle C. Monnot
    • Marcin Wegrecki
    • Annemieke de Jong
    Research
    Nature Immunology
    Volume: 24, P: 110-122

  • Germline-encoded mycolyl lipid-reactive (GEM) T cells recognize CD1b proteins presenting mycobacterial mycolates via their T-cell receptors (TCRs). Here, the authors present the structure of this interaction and provide a molecular basis for the co-recognition of CD1b and a mycobacterial glycolipid.

    • Stephanie Gras
    • Ildiko Van Rhijn
    • Jamie Rossjohn
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-12

  • Sakthivel et al. report two natural genetic variants of galectin-11 in sheep and demonstrate that their ability to dimerise correlates with the differences in their anti-parasitic activity that triggers larval arrest. This study provides a basis for genetic studies toward selective breeding of animals to improve their resistance to parasites.

    • Dhanasekaran Sakthivel
    • Sarah Preston
    • Travis Beddoe
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-8