Nature Search

Roads and detours for CAR T cell therapy in autoimmune diseases

Following on from its success in eradicating malignant B cells in cancer, chimeric antigen receptor (CAR) T cell therapy has been extended to treat autoimmune diseases. This Review discusses the preclinical studies and ongoing clinical trials of CAR T cells in autoimmune disorders, highlighting future opportunities and challenges.

Jérôme Avouac
Adi Barzel
Derya Unutmaz
Reviews26 Jan 2026
Nature Reviews Drug Discovery

P: 1-20
A Maluku Sea intermediate western boundary current connecting Pacific Ocean circulation to the Indonesian Throughflow

Here the authors use in situ mooring data in the Maluku Channel and the Lifamatola Passage of the Indonesian seas to show that a western boundary current transports Antarctic water from the South Pacific to the Indian Ocean.

Dongliang Yuan
Xueli Yin
Larry J. Pratt
ResearchOpen Access19 Apr 2022
Nature Communications

Volume: 13, P: 1-8
Thresholds for adding degraded tropical forest to the conservation estate

An analysis of the impact of logging intensity on biodiversity in tropical forests in Sabah, Malaysia, identifies a threshold of tree biomass removal below which logged forests still have conservation value.

Robert M. Ewers
C. David L. Orme
Cristina Banks-Leite
ResearchOpen Access17 Jul 2024
Nature

Volume: 631, P: 808-813
In vivo engineered B cells secrete high titers of broadly neutralizing anti-HIV antibodies in mice

B cells are engineered in vivo to secrete anti-HIV antibodies

Alessio D. Nahmad
Cicera R. Lazzarotto
Adi Barzel
Research09 Jun 2022
Nature Biotechnology

Volume: 40, P: 1241-1249
Integrative genotyping of cancer and immune phenotypes by long-read sequencing

Single-cell transcriptomics excel in cell subset classification and can be augmented by suitable genotype information. Here the authors devise a long-read sequencing workflow, termed nanoranger, for detection of molecular barcodes from single-cell cDNA and apply this to clonal tracking of acute myeloid leukemia and identification of complex immune phenotypes.

Livius Penter
Mehdi Borji
Catherine J. Wu
ResearchOpen Access02 Jan 2024
Nature Communications

Volume: 15, P: 1-18
Trapping light in air with membrane metasurfaces for vibrational strong coupling

The authors introduce a mid-IR metasurface fabricated by decorating a free-standing Si-membrane with air holes. The enhanced light-matter interactions in such air cavities enable vibrational strong coupling and advanced biochemical sensing.

Wihan Adi
Samir Rosas
Filiz Yesilkoy
ResearchOpen Access20 Nov 2024
Nature Communications

Volume: 15, P: 1-10
Solvent-dripping modulated 3D/2D heterostructures for high-performance perovskite solar cells

The random orientation of spontaneously formed 2D phase atop 3D perovskites limits the performance of solar cells. Here, authors introduce a meta-amidinopyridine ligand with solvent post dripping to generate highly ordered 2D perovskites, achieving maximum efficiency of 26.05% for stable devices.

Xiaoming Chang
Randi Azmi
Thomas D. Anthopoulos
ResearchOpen Access26 Jan 2025
Nature Communications

Volume: 16, P: 1-10
Experimental and theoretical investigation of the precise transduction mechanism in giant magnetoresistive biosensors

Jung-Rok Lee
Noriyuki Sato
Shan X. Wang
ResearchOpen Access05 Jan 2016
Scientific Reports

Volume: 6, P: 1-9
Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy

Narcolepsy has genetic and environmental risk factors, but the specific genetic risk loci and interaction with environmental triggers are not well understood. Here, the authors identify genetic loci for narcolepsy, suggesting infection as a trigger and dendritic and helper T cell involvement.

Hanna M. Ollila
Eilon Sharon
Emmanuel J. Mignot
ResearchOpen Access15 May 2023
Nature Communications

Volume: 14, P: 1-13
Bacteria deplete deoxynucleotides to defend against bacteriophage infection

Depletion of the deoxynucleotide pool by a family of dCTP deaminases, and a family of dGTPases, defends bacteria against phage infection.

Nitzan Tal
Adi Millman
Rotem Sorek
Research11 Jul 2022
Nature Microbiology

Volume: 7, P: 1200-1209
Most of the photons that reionized the Universe came from dwarf galaxies

An analysis of eight ultra-faint galaxies during the epoch of reionization with absolute magnitudes between −17 mag and −15 mag shows that most of the photons that reionized the Universe come from dwarf galaxies.

Hakim Atek
Ivo Labbé
Katherine E. Whitaker
Research28 Feb 2024
Nature

Volume: 626, P: 975-978
A single-cell atlas enables mapping of homeostatic cellular shifts in the adult human breast

Single-cell RNA sequencing analysis of over 800,000 human adult breast cells from 55 female donors identifies 41 cell subtypes and highlights age- and parity-dependent effects. Samples from healthy women with germline mutations in BRCA1 or BRCA2 showed signs of T cell exhaustion.

Austin D. Reed
Sara Pensa
Walid T. Khaled
ResearchOpen Access28 Mar 2024
Nature Genetics

Volume: 56, P: 652-662
Spatial-proteomics reveals phospho-signaling dynamics at subcellular resolution

Protein activity regulated by phosphorylation can result in subcellular relocation. Here, the authors present a high throughput spatial phosphoproteomics approach to profile six subcellular compartments, providing insights into EGFR and stress signalling dynamics.

Ana Martinez-Val
Dorte B. Bekker-Jensen
Jesper V. Olsen
ResearchOpen Access07 Dec 2021
Nature Communications

Volume: 12, P: 1-17
Predicting and affecting response to cancer therapy based on pathway-level biomarkers

Predicting an individual's response to therapy is an important goal for precision medicine. Here, the authors use an algorithm that takes into account the interaction type and directionality of signalling pathways in protein–protein interactions and find that their pathway analysis can predict essential genes, which may be a target for therapy.

Rotem Ben-Hamo
Adi Jacob Berger
Ravid Straussman
ResearchOpen Access03 Jul 2020
Nature Communications

Volume: 11, P: 1-16
Hallmarks of transcriptional intratumour heterogeneity across a thousand tumours

A study identifies 41 consensus gene expression meta-programs that are coordinately upregulated in subpopulations of malignant cells across tumour types, providing a comprehensive picture of hallmarks of intratumour heterogeneity.

Avishai Gavish
Michael Tyler
Itay Tirosh
Research31 May 2023
Nature

Volume: 618, P: 598-606
Evaluating the use of large language model in identifying top research questions in gastroenterology

Adi Lahat
Eyal Shachar
Eyal Klang
ResearchOpen Access13 Mar 2023
Scientific Reports

Volume: 13, P: 1-6
A highly magnified star at redshift 6.2

A massive star at a redshift of 6.2, corresponding to 900 million years after the Big Bang, is magnified greatly by lensing of the foreground galaxy cluster WH0137–08.

Brian Welch
Dan Coe
Tom Broadhurst
Research30 Mar 2022
Nature

Volume: 603, P: 815-818
Machine-learning of medical cannabis chemical profiles reveals analgesia beyond placebo expectations

Hatav et al. use machine learning to analyze chemical profiles of medical cannabis cultivars and their association to pain relief outcomes. Authors find that specific terpenoids predict pain relief outcomes in people with chronic pain, providing evidence for compound-specific therapeutic effects beyond placebo responses.

Adi Hatav
Yelena Vysotski
Dvir Aran
ResearchOpen Access16 Jul 2025
Communications Medicine

Volume: 5, P: 1-7
Advancing sustainable water use across the agricultural life cycle in the USA

A multifaceted approach integrating strategies across food production and consumption is required to advance sustainable water management in agriculture.

Huma Tariq Malik
Yael Zvulunov
Thomas Borch
Reviews19 Jun 2025
Nature Water

Volume: 3, P: 655-667
Relations between body mass index, laryngeal fat pads, and laryngeal airway configuration in adult men population

Yonatan Lahav
Meital Adi
Oded Cohen
Research16 Jun 2020
International Journal of Obesity

Volume: 45, P: 288-295
Variant in SCYL1 gene causes aberrant splicing in a family with cerebellar ataxia, recurrent episodes of liver failure, and growth retardation

Adi Shohet
Lior Cohen
Irit Krause
Research26 Sept 2018
European Journal of Human Genetics

Volume: 27, P: 263-268
Insights into tectonic hazards since the 2004 Indian Ocean earthquake and tsunami

Understanding of the Sumatran subduction zone and its hazards has increased since the 2004 Indian Ocean earthquake and tsunami. This Review commemorates the 20th anniversary of this event by outlining these insights and how they can inform future strategies to improve tsunami preparedness.

Gina M. Sarkawi
Lujia Feng
Emma M. Hill
Reviews10 Dec 2024
Nature Reviews Earth & Environment

Volume: 6, P: 17-34
Maternal prenatal stress induces sex-dependent changes in tRNA fragment families and cholinergic pathways in newborns

Shani Vaknine Treidel
Silvia M. Lobmaier
Hermona Soreq
ResearchOpen Access05 Apr 2025
Molecular Psychiatry

Volume: 30, P: 4307-4319
Sea surface temperature and current-related parameters affecting local adaptation of scalloped spiny lobster population in Indonesia’s archipelagic system

Adi Pancoro
Indriatmoko
Elfina Karima
ResearchOpen Access08 Aug 2024
Scientific Reports

Volume: 14, P: 1-11
Loss of EIF4G2 mediates aggressiveness in distinct human endometrial cancer subpopulations with poor survival outcome in patients

Sara Meril
Maya Muhlbauer Avni
Adi Kimchi
ResearchOpen Access22 Feb 2024
Oncogene

Volume: 43, P: 1098-1112
Predicting risk for Alcohol Use Disorder using longitudinal data with multimodal biomarkers and family history: a machine learning study

Sivan Kinreich
Jacquelyn L. Meyers
Bernice Porjesz
Research08 Oct 2019
Molecular Psychiatry

Volume: 26, P: 1133-1141
Anthropogenic impacts on lowland tropical peatland biogeochemistry

Tropical peatlands hold around 105 gigatonnes of carbon but are increasingly affected by anthropogenic activities. This Review describes the biogeochemistry of these systems and how deforestation, fire, drainage and agriculture are disturbing them.

Susan Page
Shailendra Mishra
Chris D. Evans
Reviews17 May 2022
Nature Reviews Earth & Environment

Volume: 3, P: 426-443
The impact of religiosity and financial literacy on financial management behavior and well-being among Indonesian Muslims

Haykal Rafif Wijaya
Sri Rahayu Hijrah Hati
Salina Kassim
ResearchOpen Access25 Jun 2024
Humanities and Social Sciences Communications

Volume: 11, P: 1-13
Emotion recognition and confidence ratings predicted by vocal stimulus type and prosodic parameters

Adi Lausen
Kurt Hammerschmidt
ResearchOpen Access17 Jun 2020
Humanities and Social Sciences Communications

Volume: 7, P: 1-17
Six3 regulates optic nerve development via multiple mechanisms

Anat Samuel
Ariel M. Rubinstein
Adi Inbal
ResearchOpen Access29 Jan 2016
Scientific Reports

Volume: 6, P: 1-14
The progression pattern of male hyrax songs and the role of climactic ending

Vlad Demartsev
Amiyaal Ilany
Eli Geffen
ResearchOpen Access05 Jun 2017
Scientific Reports

Volume: 7, P: 1-11
Revealing the architecture of protein complexes by an orthogonal approach combining HDXMS, CXMS, and disulfide trapping

Xiao et al. present an approach combining hydrogen–deuterium-exchange mass spectrometry (HDXMS), cross-linking MS (CXMS), and disulfide trapping to elucidate the architecture of protein complexes, using the β2AR-β-arrestin1 complex as an example.

Kunhong Xiao
Yang Zhao
Sheng Li
Protocols24 May 2018
Nature Protocols

Volume: 13, P: 1403-1428
AI assisted focused cardiac ultrasound in preventive cardiology – a perspective

Ido Cohen
Adi Lakritz
Elad Maor
ReviewsOpen Access26 Jun 2025
npj Cardiovascular Health

Volume: 2, P: 1-8
Plant resistome profiling in evolutionary old bog vegetation provides new clues to understand emergence of multi-resistance

Melanie Maria Obermeier
Wisnu Adi Wicaksono
Gabriele Berg
ResearchOpen Access11 Nov 2020
The ISME Journal

Volume: 15, P: 921-937
Atypical changes in DRG neuron excitability and complex pain phenotype associated with a Na_v1.7 mutation that massively hyperpolarizes activation

Jianying Huang
Malgorzata A. Mis
Stephen G. Waxman
ResearchOpen Access29 Jan 2018
Scientific Reports

Volume: 8, P: 1-13
Expanded diversity of microbial groups that shape the dissimilatory sulfur cycle

Karthik Anantharaman
Bela Hausmann
Jillian F. Banfield
ResearchOpen Access21 Feb 2018
The ISME Journal

Volume: 12, P: 1715-1728
First integrative trend analysis for a great ape species in Borneo

Truly Santika
Marc Ancrenaz
Erik Meijaard
ResearchOpen Access07 Jul 2017
Scientific Reports

Volume: 7, P: 1-16
Fundamental social motives measured across forty-two cultures in two waves

Cari M. Pick
Ahra Ko
Michael E. W. Varnum
ResearchOpen Access16 Aug 2022
Scientific Data

Volume: 9, P: 1-12
Correction-free remotely scanned two-photon in vivo mouse retinal imaging

Adi Schejter Bar-Noam
Nairouz Farah
Shy Shoham
ResearchOpen Access01 Jan 2016
Light: Science & Applications

Volume: 5, P: e16007
Specific microbiome-dependent mechanisms underlie the energy harvest efficiency of ruminants

Sheerli Kruger Ben Shabat
Goor Sasson
Itzhak Mizrahi
ResearchOpen Access06 May 2016
The ISME Journal

Volume: 10, P: 2958-2972
Autophagy as a cell death and tumor suppressor mechanism

Devrim Gozuacik
Adi Kimchi
Reviews12 Apr 2004
Oncogene

Volume: 23, P: 2891-2906
DAP5 and IRES-mediated translation during programmed cell death

L Marash
A Kimchi
News08 Apr 2005
Cell Death & Differentiation

Volume: 12, P: 554-562

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