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Showing 1–5 of 5 results
Advanced filters: Author: Aditya L. Surapaneni Clear advanced filters

  • Here, the authors describe a noncoding genetic variant in GBA1 specific to people of African ancestry that increases the risk of neurodegenerative diseases by interfering with the splicing of mRNA, resulting in lowered protein levels and activity.

    • Pilar Álvarez Jerez
    • Peter Wild Crea
    • Cornelis Blauwendraat
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 31, P: 1955-1963

  • Acute tubular injury (ATI) significantly contributes to many kidney diseases. Here, the authors identify several immune response and cellular stress plasma proteins linked to ATI severity and acute kidney injury, which may aid in non-invasive ATI assessment.

    • Insa M. Schmidt
    • Aditya L. Surapaneni
    • Sushrut S. Waikar
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-11

  • Progression of chronic kidney disease may lead to kidney failure and cardiovascular, metabolic and bone disease complications. Here, the authors conduct a large-scale proteomic study in patients with chronic kidney disease, identify numerous proteins that predict kidney failure, some of which are likely causal mediators and hence potential therapeutic targets.

    • Ruth F. Dubin
    • Rajat Deo
    • Peter Ganz
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13