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Showing 1–7 of 7 results
Advanced filters: Author: Adriano Bolondi Clear advanced filters

  • Slide-seq profiling of mouse embryos at the onset of organogenesis (embryonic days 8.5–9.5) coupled with a new three-dimensional reconstruction and visualization tool (sc3D) provides high-resolution maps of spatiotemporal gene expression dynamics.

    • Abhishek Sampath Kumar
    • Luyi Tian
    • Alexander Meissner
    ResearchOpen Access
    Nature Genetics
    Volume: 55, P: 1176-1185

  • Batki, Hetzel et al. report a lineage-tracing strategy to track extraembryonic gut endoderm cells over development. They find that these cells are eventually eliminated in a p53-dependent manner and neighbouring embryonic cells clear their remnants.

    • Julia Batki
    • Sara Hetzel
    • Alexander Meissner
    ResearchOpen Access
    Nature Cell Biology
    Volume: 26, P: 868-877

  • Weigert et al. show that an antagonistic relationship between DNA methyltransferase and Polycomb activity is globally responsible for the maintenance of intermediate methylation levels observed in trophoblast stem cells.

    • Raha Weigert
    • Sara Hetzel
    • Alexander Meissner
    ResearchOpen Access
    Nature Cell Biology
    Volume: 25, P: 579-591

  • The phenotypic consequence of 3D genome boundary disruption on developmental processes remains insufficiently understood. Here, the authors show that perturbation of a SOX17 boundary in human pluripotent stem cells interferes with proper differentiation and that germline variations affecting such boundaries are subject to selection, resulting in underrepresentation in the human population.

    • Hua-Jun Wu
    • Alexandro Landshammer
    • Franziska Michor
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-19