Nature Search

Elevated nonhomologous end-joining by AATF enables efficient DNA damage repair and therapeutic resistance in glioblastoma

Glioma stem-like cells (GSCs) contribute to therapeutic resistance via enhanced capability of DNA damage repair. Here the authors identify that the upregulated transcription factor AATF in GSCs modulates the stability and release of XRCC4 protein to promote DNA repair and resistance to radiotherapy.

Lanjuan Mi
Yan Cai
Jianghong Man
ResearchOpen Access28 May 2025
Nature Communications

Volume: 16, P: 1-19
miR-101/METTL3 axis induces autophagy by interrupting FOXG1/EIF3J-AS1 binding in gliomas

Yaping Yan
Shanshan Liu
Xiaoping Liu
ResearchOpen Access13 Dec 2025
Cell Death & Disease

Volume: 17, P: 1-15
LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores

During cell division, faithful chromosome segregation requires proper chromosome congression and dynamic maintenance of the aligned chromosomes. Here, the authors find that LUBAC promotes dynamic chromosome congression and alignment by targeting kinetochore motor CENP-E to the KMN network.

Min Wu
Yan Chang
Huiyan Li
ResearchOpen Access17 Jan 2019
Nature Communications

Volume: 10, P: 1-15
Pangenomic analysis identifies structural variation associated with heat tolerance in pearl millet

A graph-based pan-genome constructed using de novo genome assemblies of ten pearl millet accessions adapted to different climates worldwide identifies structural variations and their contribution to heat tolerance in pearl millet.

Haidong Yan
Min Sun
Linkai Huang
ResearchOpen Access02 Mar 2023
Nature Genetics

Volume: 55, P: 507-518
Suppression of mitochondrial ROS by prohibitin drives glioblastoma progression and therapeutic resistance

How ROS levels are regulated in cancer stem cells and their contribution to cancer resistance is currently not clear. Here, the authors show that prohibitin regulates mitochondrial ROS production stabilizing the peroxidase PRDX3 and this accounts for radiotherapy resistance in glioma stem-like cells.

Haohao Huang
Songyang Zhang
Jianghong Man
ResearchOpen Access17 Jun 2021
Nature Communications

Volume: 12, P: 1-16
KMT2C deficiency promotes small cell lung cancer metastasis through DNMT3A-mediated epigenetic reprogramming

Na et al. identify KMT2C deficiency as a driver of small cell lung cancer metastasis and demonstrate that it leads to epigenetic reprogramming through histone and DNA hypomethylation by upregulating DNMT3A.

Feifei Na
Xiangyu Pan
Chong Chen
Research21 Apr 2022
Nature Cancer

Volume: 3, P: 753-767
Early application value of flexible laryngoscope swallowing function assessment in patients after partial laryngectomy

Lina Jia
Chenxu Yan
Sen Zhang
ResearchOpen Access19 Feb 2025
Scientific Reports

Volume: 15, P: 1-9
Myc-mediated SDHA acetylation triggers epigenetic regulation of gene expression and tumorigenesis

Li and colleagues show how cMyc promotes tumourigenesis by promoting succinate dehydrogenase complex subunit A acetylation by activating SKP2-mediated degradation of SIRT3. This leads to succinate accumulation and consequent tumour-specific gene expression.

Shi-Ting Li
De Huang
Ping Gao
Research16 Mar 2020
Nature Metabolism

Volume: 2, P: 256-269
Timely antiretroviral prophylaxis during pregnancy effectively reduces HIV mother-to-child transmission in eight counties in China: a prospective study during 2004–2011

Qian Wang
Linhong Wang
Lei Zhang
ResearchOpen Access10 Oct 2016
Scientific Reports

Volume: 6, P: 1-8
LincRNA 1700020I14Rik alleviates cell proliferation and fibrosis in diabetic nephropathy via miR-34a-5p/Sirt1/HIF-1α signaling

Ailing Li
Rui Peng
Zheng Zhang
ResearchOpen Access27 Apr 2018
Cell Death & Disease

Volume: 9, P: 1-16
Genome-wide survey of switchgrass NACs family provides new insights into motif and structure arrangements and reveals stress-related and tissue-specific NACs

Haidong Yan
Ailing Zhang
Linkai Huang
ResearchOpen Access08 Jun 2017
Scientific Reports

Volume: 7, P: 1-15
Loss of PICH promotes chromosome instability and cell death in triple-negative breast cancer

Yan Huang
Wanjin Li
Tao Zhou
ResearchOpen Access03 Jun 2019
Cell Death & Disease

Volume: 10, P: 1-13
Transcriptome profiles of three Muscat table grape cultivars to dissect the mechanism of terpene biosynthesis

Lei Sun
Baoqing Zhu
Haiying Xu
ResearchOpen Access13 Jun 2019
Scientific Data

Volume: 6, P: 1-6
Genome-wide identification, phylogenetic and expression pattern analysis of MADS-box family genes in foxtail millet (Setaria italica)

Dili Lai
Jun Yan
Jianping Cheng
ResearchOpen Access23 Mar 2022
Scientific Reports

Volume: 12, P: 1-17
Progranulin improves neural development via the PI3K/Akt/GSK-3β pathway in the cerebellum of a VPA-induced rat model of ASD

Lili Wang
Jianhui Chen
Di Chen
ResearchOpen Access22 Mar 2022
Translational Psychiatry

Volume: 12, P: 1-14
Efficacy of Type 2 PRRSV vaccine against challenge with the Chinese lineage 1 (NADC30-like) PRRSVs in pigs

Chunhua Wei
Ailing Dai
Jiankui Liu
ResearchOpen Access25 Jul 2019
Scientific Reports

Volume: 9, P: 1-10
Hydrogen sulfide ameliorates chronic renal failure in rats by inhibiting apoptosis and inflammation through ROS/MAPK and NF-κB signaling pathways

Dongdong Wu
Ning Luo
Garrick D. Lee
ResearchOpen Access28 Mar 2017
Scientific Reports

Volume: 7, P: 1-16
The accumulation profiles of terpene metabolites in three Muscat table grape cultivars through HS-SPME-GCMS

Lei Sun
Baoqing Zhu
Haiying Xu
ResearchOpen Access02 Jan 2020
Scientific Data

Volume: 7, P: 1-6

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Elevated nonhomologous end-joining by AATF enables efficient DNA damage repair and therapeutic resistance in glioblastoma

miR-101/METTL3 axis induces autophagy by interrupting FOXG1/EIF3J-AS1 binding in gliomas

LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores

Pangenomic analysis identifies structural variation associated with heat tolerance in pearl millet

Suppression of mitochondrial ROS by prohibitin drives glioblastoma progression and therapeutic resistance

KMT2C deficiency promotes small cell lung cancer metastasis through DNMT3A-mediated epigenetic reprogramming

Early application value of flexible laryngoscope swallowing function assessment in patients after partial laryngectomy

Myc-mediated SDHA acetylation triggers epigenetic regulation of gene expression and tumorigenesis

Timely antiretroviral prophylaxis during pregnancy effectively reduces HIV mother-to-child transmission in eight counties in China: a prospective study during 2004–2011

LincRNA 1700020I14Rik alleviates cell proliferation and fibrosis in diabetic nephropathy via miR-34a-5p/Sirt1/HIF-1α signaling

Genome-wide survey of switchgrass NACs family provides new insights into motif and structure arrangements and reveals stress-related and tissue-specific NACs

Loss of PICH promotes chromosome instability and cell death in triple-negative breast cancer

Transcriptome profiles of three Muscat table grape cultivars to dissect the mechanism of terpene biosynthesis

Genome-wide identification, phylogenetic and expression pattern analysis of MADS-box family genes in foxtail millet (Setaria italica)

Progranulin improves neural development via the PI3K/Akt/GSK-3β pathway in the cerebellum of a VPA-induced rat model of ASD

Efficacy of Type 2 PRRSV vaccine against challenge with the Chinese lineage 1 (NADC30-like) PRRSVs in pigs

Hydrogen sulfide ameliorates chronic renal failure in rats by inhibiting apoptosis and inflammation through ROS/MAPK and NF-κB signaling pathways

The accumulation profiles of terpene metabolites in three Muscat table grape cultivars through HS-SPME-GCMS

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