Nature Search

Nature’s 10: ten people who helped shape science in 2022

A trail-blazing astronomer, a climate revolutionary and a transplant pioneer are some of the people behind this year’s big stories.

Ewen Callaway
Aisling Irwin
Alexandra Witze
News14 Dec 2022
Nature

Volume: 612, P: 611-625
Discovery of a small molecule TLR3 agonist adjuvant

Adjuvants are an important component of modern vaccines. Here, the authors employ a phenotypic screen of ~200k compounds and identify PVP-057, a TLR3 agonist with a simple scalable 3-step synthesis, as an adjuvant that induces durable humoral and cellular immunity to varicella-zoster virus (VZV) gE in mice.

Branden Lee
Danica Dong
David J. Dowling
ResearchOpen Access04 Dec 2025
Nature Communications

Volume: 17, P: 1-17
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
What it will take to vaccinate the world against COVID-19

A special report outlines the challenges — from unleashing the power of mRNA vaccines, to the battle for temporary relief on intellectual-property rights.

Aisling Irwin
News25 Mar 2021
Nature

Volume: 592, P: 176-178
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
Context-dependent effects of CDKN2A and other 9p21 gene losses during the evolution of esophageal cancer

Ganguli et al. show that CDKN2A loss in Barrett’s esophagus prevents esophageal adenocarcinoma initiation by counterselecting subsequent TP53 loss and report context-dependent effects of 9p21 gene co-deletions on disease progression.

Piyali Ganguli
Celia C. Basanta
Francesca D. Ciccarelli
ResearchOpen Access03 Jan 2025
Nature Cancer

Volume: 6, P: 158-174
At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

Munib Mesinovic
Xin Ci Wong
David Zucman
ResearchOpen Access16 Jul 2024
Scientific Reports

Volume: 14, P: 1-43
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Openshaw and colleagues find myeloid inflammation and complement activation signatures in patients with long COVID who were previously hospitalized.

Felicity Liew
Claudia Efstathiou
J. Eunice Zhang
ResearchOpen Access08 Apr 2024
Nature Immunology

Volume: 25, P: 607-621
Antigen specific T cells in people with obesity at five months following ChAdOx1 COVID-19 vaccination

Neil E. Wrigley Kelly
Conor De Barra
Donal O’Shea
Research08 Nov 2022
International Journal of Obesity

Volume: 47, P: 83-86
Type 1 interferons promote Staphylococcus aureus nasal colonization by inducing phagocyte apoptosis

Emilio G. Vozza
Alanna M. Kelly
Rachel M. McLoughlin
ResearchOpen Access13 Sept 2024
Cell Death Discovery

Volume: 10, P: 1-11
ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

Ali Abbas
Sheryl Ann Abdukahil
Luis Felipe Reyes
ResearchOpen Access30 Jul 2022
Scientific Data

Volume: 9, P: 1-22
Product and trial design considerations on the path towards a vaccine to combat opioid overdose

Asimenia Angelidou
Jacob A. Koster
Ofer Levy
ReviewsOpen Access19 Feb 2025
npj Vaccines

Volume: 10, P: 1-8

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Nature’s 10: ten people who helped shape science in 2022

Discovery of a small molecule TLR3 agonist adjuvant

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

A second update on mapping the human genetic architecture of COVID-19

What it will take to vaccinate the world against COVID-19

Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Context-dependent effects of CDKN2A and other 9p21 gene losses during the evolution of esophageal cancer

At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Antigen specific T cells in people with obesity at five months following ChAdOx1 COVID-19 vaccination

Type 1 interferons promote Staphylococcus aureus nasal colonization by inducing phagocyte apoptosis

ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

Product and trial design considerations on the path towards a vaccine to combat opioid overdose

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