Tissue nanotransfection (TNT) achieves non-viral vasculogenic reprogramming of the skin. Here the authors show that upregulation of TET1/2/3, limited under diabetic conditions, is effective in markedly improving TNT-induced vasculogenic outcomes thus rescuing ischemic diabetic tissue at risk.
- Sujit K. Mohanty
- Kanhaiya Singh
- Chandan K. Sen