The core mechanisms of autophagy are generally assumed to be broadly conserved between yeast and mammals. Cheng et al. show that the distribution of PtdIns(3)P between cytoplasmic and luminal leaflets of autophagosomes differs dramatically in yeast and mammalian cells, suggestive of different underlying mechanisms.
- Jinglei Cheng
- Akikazu Fujita
- Toyoshi Fujimoto
