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Showing 1–14 of 14 results

Advanced filters: Author: Alea A. Mills Clear advanced filters

A chromosome region linked to neurodevelopmental disorders influences locomotor behavior through sex-specific neural circuits

This study demonstrates that 16p11.2 hemideletion, a genetic deletion linked to neurodevelopmental disorders, affects male and female mice differently, altering specific striatal neuronal circuits and driving sex-specific behavioral changes.

Jaekyoon Kim
Yann Vanrobaeys
Ted Abel
ResearchOpen Access03 Jan 2026
Nature Communications

Volume: 17, P: 1-17
Contribution of mGluR5 to pathophysiology in a mouse model of human chromosome 16p11.2 microdeletion

Microdeletions of chromosome 16p11.2 can cause autism, but the pathogenic mechanisms remain unclear. Here the authors show that in a 16p11.2 mouse model, mGluR5 synaptic plasticity and protein synthesis are altered and that a modulator of mGluR5 reverses the cognitive deficits.

Di Tian
Laura J Stoppel
Mark F Bear
Research12 Jan 2015
Nature Neuroscience

Volume: 18, P: 182-184
BRD8 maintains glioblastoma by epigenetic reprogramming of the p53 network

BRD8 is identified as a specific epigenetic vulnerability for glioblastomas that harbour wild-type p53.

Xueqin Sun
Olaf Klingbeil
Alea A. Mills
Research21 Dec 2022
Nature

Volume: 613, P: 195-202
p63 is a p53 homologue required for limb and epidermal morphogenesis

Alea A. Mills
Binhai Zheng
Allan Bradley
Research22 Apr 1999
Nature

Volume: 398, P: 708-713
Dicer is essential for mouse development

Emily Bernstein
Sang Yong Kim
Gregory J Hannon
Research05 Oct 2003
Nature Genetics

Volume: 35, P: 215-217
Chd5 orchestrates chromatin remodelling during sperm development

Somatic histones are replaced with sperm-specific basic proteins, called protamines, during the chromatin remodelling phase of spermatogenesis. Here, the authors show that the chromatin remodelling protein Chd5 is required for histone-to-protamine replacement during spermatogenesis in mice.

Wangzhi Li
Jie Wu
Alea A. Mills
Research13 May 2014
Nature Communications

Volume: 5, P: 1-15
Throwing the cancer switch: reciprocal roles of polycomb and trithorax proteins

Polycomb and trithorax group proteins have opposing effects on chromatin, and either repress or activate gene expression, respectively. Therefore, the dynamic interplay between these protein families has complex effects on epigenetic regulation and consequently tumour biology.

Alea A. Mills
Reviews24 Sept 2010
Nature Reviews Cancer

Volume: 10, P: 669-682
Deletions linked to TP53 loss drive cancer through p53-independent mechanisms

The loss of the TP53 gene is often involved in the development of human cancer; here, the deletion of other genes in the vicinity is shown also to contribute to cancer progression in a mouse model.

Yu Liu
Chong Chen
Scott W. Lowe
Research16 Mar 2016
Nature

Volume: 531, P: 471-475
Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model

Kimberly L Stark
Bin Xu
Joseph A Gogos
Research11 May 2008
Nature Genetics

Volume: 40, P: 751-760
p63 regulates an adhesion programme and cell survival in epithelial cells

Danielle K. Carroll
Jason S. Carroll
Leif W. Ellisen
Research21 May 2006
Nature Cell Biology

Volume: 8, P: 551-561
TAp63 induces senescence and suppresses tumorigenesis in vivo

TAp63, a splice variant of the p53 homologue p63, suppresses tumorigenesis in p53-null mice by mediating Ras oncogene-induced senescence. TAp63-mediated senescence is independent of p53, but requires p21Waf/Cip1 and Rb. TAp63 overrides Ras-driven transformation, while its loss accelerates Ras oncogenesis.

Xuecui Guo
William M. Keyes
Alea A. Mills
Research08 Nov 2009
Nature Cell Biology

Volume: 11, P: 1451-1457
EZH2 regulates a SETDB1/ΔNp63α axis via RUNX3 to drive a cancer stem cell phenotype in squamous cell carcinoma

Seamus Balinth
Matthew L. Fisher
Alea A. Mills
Research21 Jul 2022
Oncogene

Volume: 41, P: 4130-4144
Reversal of synaptic and behavioral deficits in a 16p11.2 duplication mouse model via restoration of the GABA synapse regulator Npas4

Benjamin Rein
Tao Tan
Zhen Yan
Research25 Feb 2020
Molecular Psychiatry

Volume: 26, P: 1967-1979
Abnormal urethra formation in mouse models of Split-hand/split-foot malformation type 1 and type 4

Kentaro Suzuki
Ryuma Haraguchi
Gen Yamada
Research19 Sept 2007
European Journal of Human Genetics

Volume: 16, P: 36-44