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Showing 1–8 of 8 results
Advanced filters: Author: Alec P. Christie Clear advanced filters

  • In this phase 1 trial, treatment of patients with solid tumors using the focal adhesion kinase (FAK) inhibitor defactinib the RAF–MEK clamp avutometinib was safe and showed encouraging clinical responses, especially in patients with low-grade serous ovarian cancer.

    • Susana Banerjee
    • Matthew G. Krebs
    • Udai Banerji
    ResearchOpen Access
    Nature Medicine
    Volume: 31, P: 3074-3080

  • Randomised controlled experiments are the gold standard for scientific inference, but environmental and social scientists often rely on different study designs. Here the authors analyse the use of six common study designs in the fields of biodiversity conservation and social intervention, and quantify the biases in their estimates.

    • Alec P. Christie
    • David Abecasis
    • William J. Sutherland
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • The publication of ever-larger numbers of problematic papers, including fake ones generated by artificial intelligence, represents an existential crisis for the established way of doing evidence synthesis. But with a new approach, AI might also save the day.

    • Sam A. Reynolds
    • Alec P. Christie
    • William J. Sutherland
    Comments & Opinion
    Nature
    Volume: 643, P: 329-331

  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477

  • This Perspective encourages conservation practitioners to learn from past efforts to scale conservation actions in the hope that enhanced understanding of linkages between scaling, effectiveness and social justice will benefit future attempts to scale up, out and deep.

    • Thomas Pienkowski
    • Arundhati Jagadish
    • Morena Mills
    Reviews
    Nature Ecology & Evolution
    Volume: 8, P: 1804-1814

  • Richard Houlston and colleagues report a genome-wide association study for colorectal cancer. They report three loci newly associated with colorectal cancer, bringing the total number of common susceptibility loci to 20.

    • Malcolm G Dunlop
    • Sara E Dobbins
    • Richard S Houlston
    Research
    Nature Genetics
    Volume: 44, P: 770-776