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Showing 1–2 of 2 results
Advanced filters: Author: Alejandro Prats Luján Clear advanced filters

  • An enzymatic route to indazoles, scaffolds present in many drugs, has not been developed yet. Here, the authors report nitroreductase-triggered indazole formation, in which 2-nitrobenzylamine derivatives are converted to reactive nitrosobenzylamine intermediates that spontaneously cyclize and aromatize to indazoles.

    • Henrik Terholsen
    • Lisa Medema
    • Sandy Schmidt
    ResearchOpen Access
    Nature Communications
    P: 1-13

  • The selective enzymatic reduction of nitroaliphatic and nitroaromatic compounds is challenging. Here, the authors report selective (sun)light-driven photoenzymatic reduction of a wide variety of nitro compounds to aliphatic amines and amino-, azoxy- and azo-aromatics using flavin-dependent nitroreductases and chlorophyll as photocatalyst

    • Alejandro Prats Luján
    • Mohammad Faizan Bhat
    • Gerrit J. Poelarends
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-10