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Showing 1–5 of 5 results
Advanced filters: Author: Alessandro Fracassi Clear advanced filters

  • Cell membrane plasticity is governed by metabolic processes that regulate lipid composition and morphology, features that are challenging to control in synthetic systems. Using transiently stable phospholipid mimics, it is now shown that an abiotic phospholipid metabolism can generate and maintain dynamic artificial cell membranes, driving lipid enrichment and membrane phase transitions.

    • Alessandro Fracassi
    • Andrés Seoane
    • Neal K. Devaraj
    Research
    Nature Chemistry
    Volume: 17, P: 799-807

  • Lipid synthesis plays a central role in cell structure, signalling, and metabolism. Here, the authors report the abiotic formation of natural lipids in water using visible-light-driven photoredox chemistry, leading to the spontaneous assembly of protocell vesicles.

    • Peng Ji
    • Alexander Harjung
    • Neal K. Devaraj
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-10

  • For artificial cells to mimic living cells and communicate with their environment, methods for the translocation of peptides and proteins are needed. Here the authors demonstrate that genetically encoded and engineered α-hemolysin pores can be used to translocate functional peptides across lipid membranes.

    • Alexander Harjung
    • Alessandro Fracassi
    • Neal K. Devaraj
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-11

  • It is unknown what lipids formed the membranes of early life forms. Now it has been shown that protocell vesicles can assemble from diacylcysteines, which form spontaneously from cysteine and short-chain thioesters. Silica catalyses membrane formation, and protocells formed from diacylcysteine lipids are compatible with ribozyme activity.

    • Christy J. Cho
    • Taeyang An
    • Neal K. Devaraj
    Research
    Nature Chemistry
    Volume: 17, P: 148-155