HCN4 channels control cardiac pacing. Here, the authors isolated a nanobody (NB5) that binds HCN4 extracellularly in an ortholog- and isoform-specific manner and promotes its activation in sinoatrial node myocytes, leading to an increase in pacemaker rhythm.
- Atiyeh Sadat Sharifzadeh
- Roberta Castelli
- Anna Moroni
