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Showing 1–18 of 18 results
Advanced filters: Author: Alexander Chesler Clear advanced filters

  • Phenome-wide association is a novel method that links sequence variants to a spectrum of phenotypes and diseases. Here the authors generate detailed mouse genetic and phenome data which links their phenome-wide association study (PheWAS) of mouse to corresponding PheWAS in human.

    • Xusheng Wang
    • Ashutosh K. Pandey
    • Robert W. Williams
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-13

  • Functional imaging and multiplexed in situ hybridization were combined to investigate how trigeminal neurons encode heat and mechanical stimuli, revealing distinct cellular mechanisms for continuing pain, heat hypersensitivity and tactile allodynia during inflammation.

    • Nima Ghitani
    • Lars J. von Buchholtz
    • Alexander T. Chesler
    ResearchOpen Access
    Nature
    Volume: 642, P: 1016-1023

  • The mechanisms underlying deep pressure sensing are not fully understood. Here the authors demonstrate that while two individuals lacking Aβ fibers demonstrate impaired deep pressure sensing, seven individuals with PIEZO2 loss of function mutations display normal deep pressure responses.

    • Laura K. Case
    • Jaquette Liljencrantz
    • Alexander T. Chesler
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • PIEZO2 is a critical component of the mechanism by which innocuous touch causes pain (tactile allodynia). Here, authors find that the dietary fatty acid margaric acid decreases PIEZO2 function in a dose-dependent manner and counteracts neuronal mechanical sensitization by a proalgesic agent.

    • Luis O. Romero
    • Rebeca Caires
    • Valeria Vásquez
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • Insects possess refined olfactory systems that use specific receptors on their antennae. It emerges that these receptors not only detect odour molecules but, unexpectedly, can also act as ion channels.

    • Alexander Chesler
    • Stuart Firestein
    News & Views
    Nature
    Volume: 452, P: 944

  • Snakes are notoriously apt at generating 'thermal images' of predators or prey. The underlying physiology has been unclear, although in snakes such as pythons, vipers and boas, infrared signals are initially received by the pit organ. Here it is shown that pit-bearing snakes rely on heat detection by the ion channel TRPA1. This extends the sensory repertoire of the TRPA1 family of proteins, which detect chemical irritants in mammals and thermal variations in insects.

    • Elena O. Gracheva
    • Nicholas T. Ingolia
    • David Julius
    Research
    Nature
    Volume: 464, P: 1006-1011

  • The normal physiological function of the prion protein PrPC remains unknown. Here, the authors report that PrP knockout mice show altered behavior in two olfactory tasks and that PrP deficiency affects oscillatory activity in the olfactory bulb. Both the behavioral and electrophysiological phenotypes could be rescued by transgenic neuronal-specific expression of PrPC.

    • Claire E Le Pichon
    • Matthew T Valley
    • Stuart Firestein
    Research
    Nature Neuroscience
    Volume: 12, P: 60-69

  • The olfactory glomeruli represent a remarkable example of nervous system organization — each glomerulus is innervated exclusively by sensory neurons expressing one of more than 1,000 olfactory receptors. Firestein and colleagues discuss recent insights into glomerular development that highlight the importance of signalling activity in this process.

    • Dong-Jing Zou
    • Alexander Chesler
    • Stuart Firestein
    Reviews
    Nature Reviews Neuroscience
    Volume: 10, P: 611-618

  • The millimetre image of the Centaurus A nucleus by the Event Horizon Telescope reveals a highly collimated, asymmetrically edge-brightened jet. The source’s event horizon shadow should be visible at terahertz frequencies, consistent with the universal scale invariance of black holes.

    • Michael Janssen
    • Heino Falcke
    • Shan-Shan Zhao
    ResearchOpen Access
    Nature Astronomy
    Volume: 5, P: 1017-1028

  • Inbred mice are preferred over outbred mice because it is assumed that they display less trait variability. We compared coefficients of variation and did not find evidence of greater trait stability in inbred mice. We conclude that contrary to conventional wisdom, outbred mice might be better subjects for most biomedical research.

    • Alexander H. Tuttle
    • Vivek M. Philip
    • Jeffrey S. Mogil
    Comments & Opinion
    Nature Methods
    Volume: 15, P: 994-996

  • The lateral hypothalamic area (LHA) regulates fundamental aspects of innate behavior. However, the circuit-level underpinnings of LHA function are poorly understood given its cellular heterogeneity. Here, Mickelsen et al. employ a single-cell RNA-sequencing approach to classify molecularly distinct cell types in the mouse LHA.

    • Laura E. Mickelsen
    • Mohan Bolisetty
    • Alexander C. Jackson
    Research
    Nature Neuroscience
    Volume: 22, P: 642-656

  • The goal of the Complex Trait Consortium is to promote the development of resources that can be used to understand, treat and ultimately prevent pervasive human diseases. Existing and proposed mouse resources that are optimized to study the actions of isolated genetic loci on a fixed background are less effective for studying intact polygenic networks and interactions among genes, environments, pathogens and other factors. The Collaborative Cross will provide a common reference panel specifically designed for the integrative analysis of complex systems and will change the way we approach human health and disease.

    • Gary A Churchill
    • David C Airey
    • Fei Zou
    Comments & Opinion
    Nature Genetics
    Volume: 36, P: 1133-1137