Glioblastoma (GBM) invasion into brain parenchyma presents significant challenges for treatment. Here, the authors employ multi-omics analysis of orthotopic GBM xenograft mouse models to show that GBM cellular states are correlated both to the propensity to invade by distinct anatomical routes and to the programs that GBM cells activate during invasion.
- Rony Chanoch-Myers
- Toshiro Hara
- Itay Tirosh
