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Showing 1–5 of 5 results
Advanced filters: Author: Alexander Rittner Clear advanced filters

  • The authors report on engineering metazoan fatty acid synthase variants with tunable selectivity to obtain short- and medium-chain fatty acids, alcohols and aldehydes. Pairing these optimized enzymes with a yeast strain designed for efficient β-oxidation yields high production levels of medium-chain fatty acids.

    • Damian L. Ludig
    • Xiaoxin Zhai
    • Martin Grininger
    ResearchOpen Access
    Nature Chemical Biology
    P: 1-9

  • The introduction of fluorine into a drug molecule can alter the biological responses to it, including modulating bioavailability, pharmacokinetics and selectivity. Now, a hybrid polyketide/fatty acid synthase multienzyme has been designed to incorporate fluorinated precursors during polyketide biosynthesis in an approach that provides new chemoenzymatic access to fluorinated natural compounds.

    • Alexander Rittner
    • Mirko Joppe
    • Martin Grininger
    Research
    Nature Chemistry
    Volume: 14, P: 1000-1006

  • The Bronze-age Indus civilisation (4.6–3.9 ka) was thought to have been linked to the development of water resources in the Himalayas. Here, the authors show that along the former course of the Sutlej River the Indus settlements developed along the abandoned river valley rather than an active Himalayan river.

    • Ajit Singh
    • Kristina J. Thomsen
    • Sanjeev Gupta
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-14