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Showing 1–7 of 7 results
Advanced filters: Author: Alexandra Avgustinova Clear advanced filters

  • How cancer-associated fibroblasts become activated to support metastasis is not well understood. Here, Avgustinova et al. show that tumour cell-derived Wnt7a activates TGFβ signaling in fibroblasts, inducing them to remodel the microenvironment to the state, which promotes tumour invasiveness and metastasis.

    • Alexandra Avgustinova
    • Marjan Iravani
    • Clare M. Isacke
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-14

  • Despite frequent AKT/mTOR pathway activation in patient’s rhabdomyosarcoma (RMS), success of AKT inhibitors in the clinical has been limited. Here, using RMS patient-derived models, the authors demonstrate that the efficacy of the AKT inhibitor, ipatasertib, is in part due to its off-target effects on PRKG1, identifying PRKG1 as a potential biomarker for ipatasertib response.

    • Estela Prada
    • Pablo Táboas
    • Jaume Mora
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-25

  • The role of epigenetic regulation in adult stem cell function depends on the specific tissue and factor, but it commonly affects stem cell maintenance, self-renewal and differentiation without disrupting germ-layer fate.

    • Alexandra Avgustinova
    • Salvador Aznar Benitah
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 17, P: 643-658

  • Human oral carcinoma cells expressing high levels of the fatty acid receptor CD36 initiate metastasis in mouse models, and metastasis is increased by palmitic acid or a fatty diet and decreased by blockade of CD36.

    • Gloria Pascual
    • Alexandra Avgustinova
    • Salvador Aznar Benitah
    Research
    Nature
    Volume: 541, P: 41-45

  • Although IL-23 is expressed by psoriatic keratinocytes as well as immune cells, only the immune cell derived IL-23 is thought to be important for the development of psoriasis. Here the authors provide evidence that keratinocyte-produced IL-23 is sufficient to cause a chronic skin inflammation.

    • Hui Li
    • Qi Yao
    • Cord Brakebusch
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-18