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Showing 1–4 of 4 results
Advanced filters: Author: Alexis N. Brumwell Clear advanced filters

  • Kathiriya et al. report that fibrotic signalling in the lung mesenchyme leads to transdifferentiation of human alveolar type 2 cells into KRT5+ basal cells, providing a mechanistic explanation for the pathology associated with severe lung injuries.

    • Jaymin J. Kathiriya
    • Chaoqun Wang
    • Tien Peng
    Research
    Nature Cell Biology
    Volume: 24, P: 10-23

  • Human respiratory bronchioles contain a unique population of secretory cells called respiratory airway secretory cells that are distinct from the cells in the larger proximal airways, and act as unidirectional progenitors for alveolar type 2 cells.

    • Maria C. Basil
    • Fabian L. Cardenas-Diaz
    • Edward E. Morrisey
    Research
    Nature
    Volume: 604, P: 120-126

  • Xi et al. show that after influenza infection, hypoxia drives Notch signalling to expand Krt5+ basal-like cells in the lung. On HIF1α loss, epithelial progenitors directly differentiate into alveolar type II cells and promote functional regeneration.

    • Ying Xi
    • Thomas Kim
    • Andrew E. Vaughan
    Research
    Nature Cell Biology
    Volume: 19, P: 904-914

  • Lineage-tracing experiments identify a rare, undifferentiated population of quiescent cells in the mouse distal lung that are activated through a Notch signalling pathway to repair the epithelium after bleomycin- or influenza-mediated injury; inappropriate Notch signalling may be a major contributor to failed regeneration within the lungs of patients with chronic lung disease.

    • Andrew E. Vaughan
    • Alexis N. Brumwell
    • Harold A. Chapman
    Research
    Nature
    Volume: 517, P: 621-625