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Showing 1–9 of 9 results
Advanced filters: Author: Alicia Harbin Clear advanced filters

  • Thin-film composite membranes for reverse osmosis process are effective converting seawater and brackish water into potable water but usually they are not resistant to chlorine and the boron rejection is poor. Here, the authors show a supramolecular nanocrystalline membrane with ultrathin thickness and well-oriented sub-nano-sized channels to allow for high water permeance, sodium chloride and boron rejection as well as chlorine resistance.

    • Gang Lu
    • Wentao Shang
    • Alicia Kyoungjin An
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • Membranes with a balance between water permeability and salt rejection are desirable, and can be developed through self-assembly and aggregation. Here, the authors report a hydrogen-bonding strategy in a nanoconfined space to give controlled crystallisation, for membranes for reverse osmosis.

    • Gang Lu
    • Hubao A
    • Shuang Zheng
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11

  • Using structural, biochemical, and functional assays, the authors demonstrate that the E3 ligase KLHDC2, via newly developed small-molecule ligands, can be co-opted to target critical targets for degradation.

    • Christopher M. Hickey
    • Katherine M. Digianantonio
    • Miklós Békés
    Research
    Nature Structural & Molecular Biology
    Volume: 31, P: 311-322

  • The sinus node generates rhythmic heartbeat but the molecular basis of pacemaking is still under debate. Here, the authors combine quantitative proteomics and single-nucleus transcriptomics to characterize the molecular composition of the sinus node and provide insights into the underpinnings of pacemaking.

    • Nora Linscheid
    • Sunil Jit R. J. Logantha
    • Alicia Lundby
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-19

  • PROTACs enable targeted protein degradation by recruiting an E3 ligase to a specific substrate but the determinants of selectivity are not fully understood. Here, the authors show that varying the linker between warhead and E3 ligand and the orientation of the E3 ligase allow tuning PROTAC selectivity toward different p38 isoforms.

    • Blake E. Smith
    • Stephen L. Wang
    • Craig M. Crews
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • CAR T-cell therapy efficacy in solid tumors is limited by inadequate T-cell migration and/or persistence in tumour microenvironment. Here, the authors show that the activity of tumour-antigen specific CAR T cells, in multiple preclinical mouse models, can be enhanced by co-expression of two IL-8 receptors that mediate their migration into the tumor microenvironment when IL-8 production in tumor is naturally expressed or enhanced by radiation.

    • Linchun Jin
    • Haipeng Tao
    • Jianping Huang
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • SMARCA2 has been identified as a synthetic lethal target in SMARCA4 mutated tumors, however, homology between the two has hindered the development of selective SMARCA2 inhibitors. Here, the authors synthesize a proteolysis targeting chimera (PROTAC) capable of SMARCA2 specific degradation and demonstrate its utility in the treatment of SMARCA4 mutated tumors.

    • Jennifer Cantley
    • Xiaofen Ye
    • Robert L. Yauch
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14