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Showing 1–6 of 6 results

Advanced filters: Author: Alison D. Axtman Clear advanced filters

Advances in BRET probes for intracellular target engagement studies

This Perspective highlights advances in bioluminescence resonance energy transfer technologies for measuring intracellular drug–target engagement, expanding their use to analyze kinetics, permeability and complex mechanisms in chemical biology.

Jacob L. Capener
Martin P. Schwalm
Matthew B. Robers
Reviews06 Jan 2026
Nature Chemical Biology

P: 1-11
BRSK2 plays a role in autophagy and cancer cell growth and survival under nutrient deprivation stress via the PIK3C3 pathway

Aparna Maiti
Alison D. Axtman
Nitai C. Hait
ResearchOpen Access19 Nov 2025
Scientific Reports

Volume: 15, P: 1-23
CDK16: the pick of the understudied PCTAIRE kinases

Alison Axtman
David Drewry
Carrow Wells
News21 May 2019
Nature Reviews Drug Discovery

Volume: 18, P: 489
Modulation of tau tubulin kinases (TTBK1 and TTBK2) impacts ciliogenesis

Frances M. Bashore
Ariana B. Marquez
Alison D. Axtman
ResearchOpen Access14 Apr 2023
Scientific Reports

Volume: 13, P: 1-17
PKIS deep dive yields a chemical starting point for dark kinases and a cell active BRSK2 inhibitor

Tigist Y. Tamir
David H. Drewry
Alison D. Axtman
ResearchOpen Access28 Sept 2020
Scientific Reports

Volume: 10, P: 1-12
Protein–ligand data at scale to support machine learning

Target 2035 aims to develop a potent and selective pharmacological modulator for every human protein by 2035 with the results made publicly available. This Roadmap article sets out how that will be achieved.

Aled M. Edwards
Dafydd R. Owen
Suzanne Ackloo
Reviews23 Jul 2025
Nature Reviews Chemistry

Volume: 9, P: 634-645