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Showing 1–18 of 18 results
Advanced filters: Author: Allison C. Michaelis Clear advanced filters

  • Crystal structures of α-L-iduronidase, the enzyme linked to MPS I, now provide snapshots of the catalytic pathway and rationalize the role of 100 disease-related mutations, while biochemical analysis of deglycosylated and mutated enzymes define roles for non–active site residues in controlling function.

    • Haiying Bie
    • Jiang Yin
    • Michael N G James
    Research
    Nature Chemical Biology
    Volume: 9, P: 739-745

  • Earth system models (ESMs) generally have crude representations of the responses of soil carbon responses to changing climate. Now an ESM that explicitly represents microbial soil carbon cycling mechanisms is able to simulate carbon pools that closely match observations. Projections from this model produce a much wider range of soil carbon responses to climate change over the twenty-first century than conventional ESMs.

    • William R. Wieder
    • Gordon B. Bonan
    • Steven D. Allison
    Research
    Nature Climate Change
    Volume: 3, P: 909-912

  • Engineering enzymes to utilize the noncanonical redox cofactors such as nicotinamide mononucleotide (NMN + ) is challenging. Here, the authors report a growth-based selection platform for NMN + -reducing enzyme engineering and show its application in developing a phosphite dehydrogenase with improved catalytic efficiency.

    • Linyue Zhang
    • Edward King
    • Han Li
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • An analysis of T cell responses in people with amyotrophic lateral sclerosis shows that the C9orf72 antigen is a key target of autoimmune responses in the disease, and identifies C9orf72 epitopes that are recognized.

    • Tanner Michaelis
    • Cecilia S. Lindestam Arlehamn
    • Alessandro Sette
    ResearchOpen Access
    Nature
    Volume: 647, P: 970-978

  • Acclimation of tree photosynthesis to warming may be affected by elevated CO2. Here, the authors show that mature boreal conifers may be able to maintain leaf-level C uptake under warming and elevated CO2 even if optimum temperature of photosynthesis does not track increased temperature.

    • Mirindi Eric Dusenge
    • Jeffrey M. Warren
    • Danielle A. Way
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-11

  • Whether rising temperatures will reduce global soil carbon stocks and enhance climate warming remains uncertain, in part because of a poor understanding of the mechanisms of soil microbial response to warming. Research now shows that microbial growth efficiency is insensitive to temperature change and that the response of microbial respiration to warming is driven by accelerated microbial turnover and enzyme kinetics.

    • Shannon B. Hagerty
    • Kees Jan van Groenigen
    • Paul Dijkstra
    Research
    Nature Climate Change
    Volume: 4, P: 903-906

  • The lysosomal storage disease mucopolysaccharidosis I is treated with recombinant α-L-iduronidase but production of the enzyme is expensive. In this study, α-L-iduronidase is compartmentalized within the endosperm of maize via a unique mRNA strategy yielding the active, correctly glycosylated protein.

    • Xu He
    • Thomas Haselhorst
    • Allison R. Kermode
    Research
    Nature Communications
    Volume: 3, P: 1-9

  • During transcription, RNA polymerases may encounter protein roadblocks along template DNA. Here, Qian et al. use magnetic tweezers to show that RNA polymerases can backtrack and ram into longer lived roadblocks to transit through them.

    • Jin Qian
    • Allison Cartee
    • Laura Finzi
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-11

  • Glutaredoxin (GLRX) is a key enzyme in redox regulation via oxidation of protein cysteines and its activity is disrupted in diverse human diseases. This study integrates molecular modeling and biochemical validation to provide insights into the mechanisms of oxidative inactivation of GLRX.

    • Elizabeth M. Corteselli
    • Mona Sharafi
    • Yvonne M. W. Janssen-Heininger
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • DNA supercoiling can result in underwinding with negative supercoiling or overwinding with positive supercoiling of the DNA double helix. Here the authors reveal insights into the dynamic relationship between DNA supercoiling-induced sequence-dependent disruptions to base pairing, DNA looping, and the shape of the DNA molecule.

    • Jonathan M. Fogg
    • Allison K. Judge
    • Lynn Zechiedrich
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • Polycomb group proteins are involved in the epigenetic maintenance of repressive chromatin states, with the gene-silencing activity of the Polycomb repressive complex 2 (PRC2) dependent on its ability to trimethylate lysine 27 of histone H3. The carboxy-terminal domain of the EED subunit of the complex is now shown to specifically bind to histone tails carrying trimethyl-lysine residues associated with repressive chromatin marks, leading to activation of the methyltransferase activity of PRC2.

    • Raphael Margueron
    • Neil Justin
    • Steven J. Gamblin
    Research
    Nature
    Volume: 461, P: 762-767

  • In this Review, Lopatkin and Collins discuss key areas of predictive biology that are of growing interest to microbiology, the challenges associated with the innate complexity of microorganisms and the value of quantitative methods in making microbiology more predictable.

    • Allison J. Lopatkin
    • James J. Collins
    Reviews
    Nature Reviews Microbiology
    Volume: 18, P: 507-520

  • Conventional structure-based design of Mpro inhibitors of SARS-CoV-2 often starts from the structural information of Mpro and their binders; however, the continual rise of resistant strains requires innovative routes to discover new inhibitors. Here, the authors develop a DNA-encoded chemical library screening to produce non-covalent, non-peptidic small molecule inhibitors for SARS-CoV-2 Mpro independently of preliminary knowledge regarding suitable starting points.

    • Ravikumar Jimmidi
    • Srinivas Chamakuri
    • Damian W. Young
    ResearchOpen Access
    Communications Chemistry
    Volume: 6, P: 1-10