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Proapoptotic Bcl-2 inhibitor as potential host directed therapy for pulmonary tuberculosis

Mycobacterium tuberculosis prevents host-cell apoptosis, causing necrosis and fibrosis, leading to tissue damage. Singh et al. show that strategic targeting of apoptosis with Bcl-2 inhibitors may enhance TB treatments and be protective against post-TB lung disease.

Medha Singh
Mona O. Sarhan
Sanjay K. Jain
ResearchOpen Access27 Mar 2025
Nature Communications

Volume: 16, P: 1-13
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Dynamic ¹⁸F-Pretomanid PET imaging in animal models of TB meningitis and human studies

Pretomanid has been approved for use in cases of multi-drug resistant pulmonary tuberculosis, yet the penetration of this antibiotic into other target tissues is not well established. Authors provide insight on pretomanid pharmacokinetics in the central nervous system, using positron emission tomography in animal models, and human studies.

Filipa Mota
Camilo A. Ruiz-Bedoya
Sanjay K. Jain
ResearchOpen Access29 Dec 2022
Nature Communications

Volume: 13, P: 1-9
Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer

The competitive dynamics of mitochondrial haplotypes juxtaposed within the same cell are poorly studied. Here the authors show, in the context of a transmissible cancer, that one haplotype has recurrently entered cancer cells by horizontal transfer and appears to have a ‘selfish’ selective advantage.

Andrea Strakova
Thomas J. Nicholls
Elizabeth P. Murchison
ResearchOpen Access16 Jun 2020
Nature Communications

Volume: 11, P: 1-11
Mouse genome rewriting and tailoring of three important disease loci

This study describes a method to insert large stretches of exogenous DNA into mammalian genomes, which is used to insert human ACE2 loci into mouse to produce a model of human SARS-CoV-2 infection.

Weimin Zhang
Ilona Golynker
Jef D. Boeke
ResearchOpen Access01 Nov 2023
Nature

Volume: 623, P: 423-431
Non-invasive electromechanical assessment during atrial fibrillation identifies underlying atrial myopathy alterations with early prognostic value

Electromechanical characterization during atrial fibrillation (AF) remains a significant gap in the understanding of AF-related atrial myopathy. Here, the authors use non-invasive atrial electromechanical assessment during AF to identify early remodeling changes associated with underlying myopathy, which in the clinic decrease the probability of acute and mid-term successful rhythm control.

Daniel Enríquez-Vázquez
Jorge G. Quintanilla
David Filgueiras-Rama
ResearchOpen Access04 Aug 2023
Nature Communications

Volume: 14, P: 1-17
Climatic and soil factors explain the two-dimensional spectrum of global plant trait variation

The authors investigate the broad-scale climatological and soil properties that co-vary with major axes of plant functional traits. They find that variation in plant size is attributed to latitudinal gradients in water or energy limitation, while variation in leaf economics traits is attributed to both climate and soil fertility including their interaction.

Julia S. Joswig
Christian Wirth
Miguel D. Mahecha
ResearchOpen Access23 Dec 2021
Nature Ecology & Evolution

Volume: 6, P: 36-50
Tuberculous meningitis: a roadmap for advancing basic and translational research

Tuberculous meningitis is a serious, life-threatening disease affecting vulnerable populations, including HIV-infected individuals and young children. The US National Institutes of Health convened a workshop to identify knowledge gaps in the molecular and immunopathogenic mechanisms of tuberculous meningitis and to develop a roadmap for basic and translational research that could guide clinical studies.

Sanjay K. Jain
David M. Tobin
Zsuzsanna Fabry
News & Views18 May 2018
Nature Immunology

Volume: 19, P: 521-525
Dynamic imaging in patients with tuberculosis reveals heterogeneous drug exposures in pulmonary lesions

Distinct patterns of exposure to a first-line tuberculosis drug in separate lung lesions within patients are revealed by PET–CT imaging. Use of the technique might help optimize the duration and dosing of antimicrobial drugs.

Alvaro A. Ordonez
Hechuan Wang
Sanjay K. Jain
Research17 Feb 2020
Nature Medicine

Volume: 26, P: 529-534
Biomaterial-based platforms for tumour tissue engineering

Biology can help to design materials and approaches for tumour tissue engineering. Biomaterials are a requisite for modelling cancer to rebuild tissue organization, composition and function. This Review discusses bioengineering strategies that recreate the pathophysiology of tumour tissues to address questions in cancer research.

Rodrigo Curvello
Verena Kast
Daniela Loessner
Reviews14 Feb 2023
Nature Reviews Materials

Volume: 8, P: 314-330
Centromeric AA motif in KIR as an optimal surrogate marker for precision definition of alloimmune reproductive failure

Raquel Gil Laborda
Edgard Rodríguez de Frías
Silvia Sánchez-Ramón
ResearchOpen Access09 Feb 2024
Scientific Reports

Volume: 14, P: 1-10
Sulforaphane exhibits antiviral activity against pandemic SARS-CoV-2 and seasonal HCoV-OC43 coronaviruses in vitro and in mice

Sulforaphane, a chemical found in broccoli, has known antioxidant and antiinflammatory effects. Here, the authors show that it can inhibit SARS-CoV-2 and other coronavirus infections in mammalian cells and can decrease viral load in mice when treated prior to SARS-CoV-2 infection.

Alvaro A. Ordonez
C. Korin Bullen
Lorraine Jones-Brando
ResearchOpen Access18 Mar 2022
Communications Biology

Volume: 5, P: 1-11
Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico

A risk haplotype for type 2 diabetes is identified with four amino acid substitutions in SLC16A11, which is present at ∼50% frequency in Native American samples and ∼10% in east Asian samples, but is rare in European and African samples; SLC16A11 may alter hepatic lipid metabolism, causing an increase in triacylglycerol levels.

Amy L. Williams
Suzanne B. R. Jacobs
Teresa Tusié-Luna
Research25 Dec 2013
Nature

Volume: 506, P: 97-101
Serum angiopoietin-like 3 levels are elevated in obese non diabetic men but are unaffected during an oral glucose tolerance test

Maria Fernanda Garcés
Julieth Daniela Buell-Acosta
Jorge Eduardo Caminos
ResearchOpen Access03 Dec 2020
Scientific Reports

Volume: 10, P: 1-9
Global Roadkill Data: a dataset on terrestrial vertebrate mortality caused by collision with vehicles

Clara Grilo
Tomé Neves
Eric Guinard
ResearchOpen Access31 Mar 2025
Scientific Data

Volume: 12, P: 1-14

Search

Proapoptotic Bcl-2 inhibitor as potential host directed therapy for pulmonary tuberculosis

A second update on mapping the human genetic architecture of COVID-19

Dynamic ¹⁸F-Pretomanid PET imaging in animal models of TB meningitis and human studies

Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer

Mouse genome rewriting and tailoring of three important disease loci

Non-invasive electromechanical assessment during atrial fibrillation identifies underlying atrial myopathy alterations with early prognostic value

Climatic and soil factors explain the two-dimensional spectrum of global plant trait variation

Tuberculous meningitis: a roadmap for advancing basic and translational research

Dynamic imaging in patients with tuberculosis reveals heterogeneous drug exposures in pulmonary lesions

Biomaterial-based platforms for tumour tissue engineering

Centromeric AA motif in KIR as an optimal surrogate marker for precision definition of alloimmune reproductive failure

Sulforaphane exhibits antiviral activity against pandemic SARS-CoV-2 and seasonal HCoV-OC43 coronaviruses in vitro and in mice

Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico

Serum angiopoietin-like 3 levels are elevated in obese non diabetic men but are unaffected during an oral glucose tolerance test

Global Roadkill Data: a dataset on terrestrial vertebrate mortality caused by collision with vehicles

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