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Showing 1–4 of 4 results
Advanced filters: Author: Amanda Cobos-Correa Clear advanced filters

  • In this work, fragments identified by 19F-NMR are optimized into submicromolar binders of the MITF transcription factor. These results support direct targeting of bHLH-LZ DNA binding domains and provide a foundation for the development of new melanoma therapies.

    • Deborah Castelletti
    • Jürgen Hinrichs
    • Wolfgang Jahnke
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-18

  • Lineage-restricted transcription factor PAX8 is oncogenic in ovarian cancer cells. Here the authors show that PAX8 interacts and recruits a splice variant of the MECOM locus PRDM3 to control the gene expression module involved in adhesion and extracellular matrix, and consequently promotes ovarian tumorigenesis.

    • Melusine Bleu
    • Fanny Mermet-Meillon
    • Giorgio Giacomo Galli
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • Unique activities and high potency at disease-relevant biological targets can now be identified for ‘dark chemical matter’—compounds in high-throughput screening libraries that have been extensively tested but that have never been annotated as having biological activity.

    • Anne Mai Wassermann
    • Eugen Lounkine
    • Meir Glick
    Research
    Nature Chemical Biology
    Volume: 11, P: 958-966