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Integration of mosquito and non-human primate surveillance and viral metagenomics reveals yellow fever virus outbreak dynamics at an urban–forest interface in Brazil.

The APOE-ε4 allele is the strongest genetic risk factor for late-onset Alzheimer’s disease, but it is not deterministic. Here, the authors show that common genetic variation changes how APOE-ε4 influences cognition.

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Many animals adapt their behaviour according to their surroundings. Here, Bateset al.show that animals living in deep-sea hydrothermal vents choose habitats within their thermal limits.

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Mycobacterium tuberculosis protein Ku is involved in DNA repair and a potential drug target. Here, using cryo-EM and complementary approaches, the authors obtain insights into Ku oligomerization and mechanisms of function in DNA synapsis.

A consensus cell type atlas for the fly brain provides both an intellectual framework and open-source toolchains for brain-scale comparative connectomics.

FlyWire presents a neuronal wiring diagram of the whole fly brain with annotations for cell types, classes, nerves, hemilineages and predicted neurotransmitters, with data products and an open ecosystem to facilitate exploration and browsing.

Ecologists must understand how marine life responds to changing local conditions, rather than to overall global temperature rise, say Amanda E. Bates and 16 colleagues.

Here, the authors show that neutralization of human sera from both BNT162b2 vaccine recipients and from convalescent COVID-19 patients is less efficient against SARS- CoV-2 variants B.1.1.7 and B.1.351 and negatively associated with patient age.

Biodiversity time series from temperate regions reveal that marine communities in warmer places gain species but lose individuals with warming, but colder environments show weaker trends, whereas no systematic relationships between biodiversity and temperature change were detectable for terrestrial communities.

The authors use 12 years of broadscale survey data across 838 temperate and tropical coastal sites to investigate shifts in marine taxa range edges at the community level. They show that while some species respond rapidly to change, evidence for mass poleward migration is limited.

Openshaw and colleagues find myeloid inflammation and complement activation signatures in patients with long COVID who were previously hospitalized.

A systematic census at 1,636 sites around Australia from 2008 to 2021 finds that more than 30% of shallow invertebrate species in cool latitudes exhibit a high extinction risk due to declining populations and oceanic barriers, but tropical coral species remain relatively stable.

Species identity and richness both contribute biodiversity-ecosystem functioning relationships. Here the authors apply a decomposition approach inspired by the Price equation to a global dataset of reef fish community biomass, finding that increased richness and community compositions favouring large-bodied species enhance biomass.

Whether multimorbidity accelerates brain Aβ deposition in humans remains largely unknown. Here, the authors demonstrate that higher self-reported multimorbidity burden predicts increased brain Aβ accumulation rates in the ADNI cohort.

Protected areas are meant to defend species from direct exploitation and habitat loss, but they might also reduce climate change impacts. Here, the authors show that marine protected areas mitigate the impacts of marine heatwaves on reef fish communities.

Animal diversity, measured in numbers of species, is rapidly being lost to extinction. Here, Cooke et al. show that the diversity of ecological strategies employed by land mammals and birds is also expected to narrow towards small, fecund, insect-eating generalists with fast-paced life histories.

The marine environment is under threat from climate change. This study finds that marine reserves can maintain biodiversity and abundance of large-bodied individuals in a warming environment. They also protect against colonization by range-shifting species when compared with fished sites.

Analysis of diet and body size in terrestrial and aquatic vertebrates shows that a U-shaped relationship between body size and trophic guild prevails across extant vertebrates with the exception of marine mammals and seabirds. Analysis of fossil data shows that, for terrestrial mammals, this pattern has persisted for at least 66 million years, despite anthropogenic perturbance, which may have greater effects in the next centuries.

The COVID-19 lockdown reduced human mobility and led to immediate insights into how humans impact nature. Yet the strongest ecological impacts are likely to come. As we emerge from the pandemic, governments should avoid prioritizing short-term economic gains that compromise ecosystems and the services they provide humanity. Instead, the pandemic can be a pivot point for societal transformation to value longer term ecosystem and economic sustainability.

Marine protected areas aim to conserve biodiversity and habitat. However continued high emissions causing changes in sea-surface temperatures and oxygen levels are likely to disrupt many ecosystems protected by MPAs.

Using a species generalization index calculated from a global dataset of reef fishes and their habitats, the authors show that generalist species respond more successfully to habitat disruption and are better able to move polewards in response to climate change.

Using a comprehensive data set of thermal tolerance limits, latitudinal range boundaries and latitudinal range shifts of cold-blooded animals, this study explores the likely consequences of climate change for the geographical redistribution of terrestrial and marine species at a global scale.

Nicholas Payne et al. use physiological and population-level abundance data from 823 fish species to examine how heating tolerance scales at both the individual and population level. This study shows that heating tolerance declines in the lab and the wild at the same rate, and for a given temperature, individuals and populations from tropical areas have broader heating tolerances than temperate species.

Assessing the relationship between sea temperature and distributional range for 1,790 shallow-water marine species, the authors find that realized thermal niches increase with latitude, despite decreases in geographic range size.

How marine communities will respond to climate change depends on the thermal sensitivities of existing communities; existing reef communities do not show a perfect fit between current temperatures and the thermal niches of the species within them and this thermal bias is a major contributor to projected local species loss.

The NOPE1 gene is required for arbuscular mycorrhizal symbiosis in maize. The causal gene is now identified using rice. It is the first identified GlcNAc transporter in plants, needed for presymbiotic fungal reprogramming.

Whole-genome sequencing analysis of individuals with primary immunodeficiency identifies new candidate disease-associated genes and shows how the interplay between genetic variants can explain the variable penetrance and complexity of the disease.

The authors summarize the data produced by phase III of the Encyclopedia of DNA Elements (ENCODE) project, a resource for better understanding of the human and mouse genomes.

The interplay between amyloid and tau pathology in Alzheimer’s disease is still not well understood. Here, the authors show that amyloid-related increased in soluble p-tau is related to subsequent accumulation of tau aggregates and cognitive decline in early stage of the disease.

Emerging variants of SARS-CoV-2 raise concerns about vaccine efficiency. Here, the authors present a post-hoc analysis for the ChAdOx1 nCoV-19 (AZD1222) vaccine trial in Brazil and provide efficacy against symptomatic COVID-19 caused by the Zeta (P.2) and other variants.

Neural processing speed slows with age, but the relationship between this slowing and brain atrophy is unknown. Here, authors show that age-related functional brain differences in auditory and visual processing are partly due to structural differences in the distinct brain regions underlying these processes.

This study finds that sST2 is a disease-causing factor for Alzheimer’s disease. Higher sST2 levels impair microglial Aβ clearance in APOE4⁺ female individuals. A genetic variant, rs1921622, is associated with a reduction in sST2 level and protects against AD in APOE4⁺ female individuals.

Theory predicts that winds expel baryons from galaxies into intergalactic space; now optical observations of the massive, but compact, galaxy SDSS J211824.06+001729.4 show that it is ejecting an enormous ionized outflow of gas.

Tau accumulation is associated with disease progression in Alzheimer’s disease. Here the authors use resting state fMRI and tau-PET to demonstrate that baseline connectivity in Alzheimer's disease is associated with tau spreading.

Alzheimer’s disease is heterogeneous in its neuroimaging and clinical phenotypes. Here the authors present a semi-supervised deep learning method, Smile-GAN, to show four neurodegenerative patterns and two progression pathways providing prognostic and clinical information.

Alzheimer’s disease has been associated with increased structural brain aging. Here the authors describe a model that predicts brain aging from resting state functional connectivity data, and demonstrate this is accelerated in individuals with pre-clinical familial Alzheimer’s disease.

In this study the authors identify a possible link between the gene FAM222A and brain atrophy. The protein it encodes is found to accumulate in plaques seen in Alzheimer’s disease, and functional analysis suggests it interacts with amyloid-beta.

The KL-VS haplotype of the Klotho gene has been associated with reduced risk of Alzheimer’s disease and dementia. Here the authors show an association between the KL-VS haplotype and amyloid-dependent tau accumulation using PET data.

The BIN1 SNP rs744373 is associated with higher CSF tau and phosphorylated tau levels. Here the authors show, using PET imaging, that this SNP is associated with tau accumulation in the brain as well as impaired memory in older individuals without dementia.