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Showing 1–4 of 4 results

Advanced filters: Author: Amandeep Girdhar Clear advanced filters

Engineered NLS-chimera downregulates expression of aggregation-prone endogenous FUS

This study developed a FUS chimera (FUSIBB) with a highly efficient anti-aggregation signal that is engaged by a nuclear import receptor, Importin beta. FUSIBB can mitigate aggregation and reduce expression of a neurodegeneration-linked protein, FUS.

Miyuki Hayashi
Amandeep Girdhar
Lin Guo
ResearchOpen Access10 Sept 2024
Nature Communications

Volume: 15, P: 1-20
NLS-binding deficient Kapβ2 reduces neurotoxicity via selective interaction with C9orf72-ALS/FTD dipeptide repeats

The NLS-binding deficient Kapβ2W460A:W730A was shown to be able to selectively target R-DPRs without disrupting normal FUS assembly, which offers a potential therapeutic avenue for C9 ALS/FTD.

Kevin M. Kim
Amandeep Girdhar
Lin Guo
ResearchOpen Access02 Jan 2025
Communications Biology

Volume: 8, P: 1-20
An acridine derivative, [4,5-bis{(N-carboxy methyl imidazolium)methyl}acridine] dibromide, shows anti-TDP-43 aggregation effect in ALS disease models

Archana Prasad
Gembali Raju
Basant K. Patel
ResearchOpen Access21 Dec 2016
Scientific Reports

Volume: 6, P: 1-14
Synthesis and implication of novel poly(acrylic acid)/nanosorbent embedded hydrogel composite for lead ion removal

Mayuri Bhatia
Satish Babu Rajulapati
Amandeep Girdhar
ResearchOpen Access27 Nov 2017
Scientific Reports

Volume: 7, P: 1-16