Isolation of antigen-reactive T cell receptors (TCRs) to cancer epitopes is important for engineered T cell immunotherapies. Here the authors show an aptamer-based microfluidic single-cell method to isolate antigen-reactive TCRs and show proof of principle isolations for cytomegalovirus and prostate specific antigen.
- Siwei Luo
- Amber Notaro
- Lan Lin
