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Advanced filters: Author: Amira El Merhie Clear advanced filters

Endothelin-3 and T-type Ca²⁺ channels drive enteric neural crest cell calcium activity, contractility and migration

Neural crest cells migrate in the embryo to form the gut’s nervous system. Researchers found that endothelin-3 triggers electrical oscillations via T-type calcium channels, enabling these cells to contract like ‘mini muscles’ and colonize organs.

Nicolas R. Chevalier
Fanny Gayda
Léna Zig
ResearchOpen Access20 Jan 2026
Nature Communications

P: 1-13
Calcium wave dynamics in the embryonic mouse gut mesenchyme: impact on smooth muscle differentiation

Calcium waves underpin smooth muscle contractions in the gut. The authors examine their developmental dynamics, molecular properties and their impact on differentiation of smooth muscle and interstitial cells of Cajal in the mouse embryo.

Nicolas R. Chevalier
Léna Zig
Sandrine Faure
ResearchOpen Access07 Oct 2024
Communications Biology

Volume: 7, P: 1-11

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Endothelin-3 and T-type Ca2+ channels drive enteric neural crest cell calcium activity, contractility and migration

Calcium wave dynamics in the embryonic mouse gut mesenchyme: impact on smooth muscle differentiation

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Endothelin-3 and T-type Ca²⁺ channels drive enteric neural crest cell calcium activity, contractility and migration