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Showing 1–9 of 9 results
Advanced filters: Author: Amirhossein Mafi Clear advanced filters

  • The adenosine A2A receptor (A2AR) plays a crucial role in regulating inflammation and metabolism, yet the extent to which endogenous metabolites modulate its activity remains unclear. Here, the authors utilized the MIDAS platform to identify metabolites interacting with A2AR, revealing orthosteric and allosteric modulators.

    • Prashant Rao
    • Manoj Rathinaswamy
    • Qi Hao
    ResearchOpen Access
    Communications Chemistry
    Volume: 9, P: 1-13

  • PAPP-A substrate selectivity underlies the tight regulation of IGF signaling. Here, the authors report cryo-EM structures of dimeric PAPP-A in its substrate-free form and in complex with a peptide substrate, which combined with biochemical assays provide a mechanism for PAPP-A substrate binding and selectivity.

    • Russell A. Judge
    • Janani Sridar
    • Qi Hao
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • HPV’s E6 protein promotes cancer by degrading p53. This study reveals the cryoEM structure of HPV16 E6 in complex with E6AP and p53, highlighting their picomolar affinity and large protein-protein interaction interface.

    • John C. K. Wang
    • Hannah T. Baddock
    • Aaron H. Nile
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • Contrary to agonist binding being the sole driver for β2-adrenergic receptor (β2AR) activation, molecular metadynamics simulations now reveal a distinct activation mechanism. Coupling β2AR with its cognate Gs protein induces considerable structural changes, activating both proteins. Gs opens its GDP binding pocket while β2AR undergoes expansion.

    • Amirhossein Mafi
    • Soo-Kyung Kim
    • William A. Goddard III
    Research
    Nature Chemistry
    Volume: 15, P: 1127-1137

  • A chemoproteomics profile of the human metabolite 20(S)-hydroxycholesterol exposes its broad connections to the immune system and cancer, revealing it to be a highly selective ligand for the orphan receptor Tmem97 (the σ2 receptor).

    • Yu-Shiuan Cheng
    • Tianyi Zhang
    • Alison E. Ondrus
    Research
    Nature Chemical Biology
    Volume: 17, P: 1271-1280

  • PAPP-A and PAPP-A2 are two isoforms of pregnancy-associated plasma protein A that cleave insulin-like growth factor binding proteins (IGFBPs) to modulate insulin-like growth factor signaling, however the structure and function of PAPP-A2 remain underexplored. Here, the authors report the cryo-EM structure of PAPP-A2, computational modeling of the PAPP-A2/IGFBP5 complex, and biochemical studies that reveal unique structural features and a lower IGFBP5 cleaving efficiency compared with PAPP-A.

    • Janani Sridar
    • Amirhossein Mafi
    • Qi Hao
    ResearchOpen Access
    Communications Chemistry
    Volume: 6, P: 1-14

  • PTPN2 (protein tyrosine phosphatase non-receptor type 2) and PTPN1 are attractive immuno-oncology targets, however, targeting PTPN2/N1 poses significant challenges. Here, the authors report the development of potent PTPN2/N1 heterobifunctional degraders and reveal biochemical and structural insights into the formation of ternary structures with cereblon E3 ligase by X-ray diffraction, cryo-EM and MD simulations.

    • Qi Hao
    • Manoj K. Rathinaswamy
    • Michael E. Kort
    ResearchOpen Access
    Communications Chemistry
    Volume: 7, P: 1-16

  • Macrocycle peptides are promising constructs for imaging and inhibiting extracellular and cell membrane proteins, but their use for targeting intracellular proteins is typically limited by poor cell penetration. Here, the authors report the development of a cell-penetrant high-affinity peptide ligand targeted to the phosphorylated Ser474 epitope of the (active) Akt2 kinase.

    • Arundhati Nag
    • Amirhossein Mafi
    • James R. Heath
    ResearchOpen Access
    Communications Chemistry
    Volume: 6, P: 1-12