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Nature Biomedical Engineering (1)
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Low reactogenicity and high tumour antigen expression from mRNA-LNPs with membrane-destabilizing zwitterionic lipids

Incorporating membrane-destabilizing zwitterionic lipids into commercially available LNPs boosts mRNA expression in antigen-presenting cells within lymph nodes, enhancing cytotoxic T cell activation, and dampens reactogenicity in mice.

Yu Zhao
Ruoxin Li
Shaoyi Jiang
Research18 Dec 2025
Nature Biomedical Engineering

P: 1-15
Cell activation-based screening of natively paired human T cell receptor repertoires

Ahmed S. Fahad
Cheng Yu Chung
Brandon J. DeKosky
ResearchOpen Access17 May 2023
Scientific Reports

Volume: 13, P: 1-11

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Low reactogenicity and high tumour antigen expression from mRNA-LNPs with membrane-destabilizing zwitterionic lipids

Cell activation-based screening of natively paired human T cell receptor repertoires

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