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Showing 1–6 of 6 results
Advanced filters: Author: Amy Langdon Clear advanced filters

  • In this work, the authors report that protein-RNA condensates with shared proteins and distinct RNAs can form and persist in vitro and in cells as distinct entities if the nonshared RNA molecules are dynamically arrested, but the shared protein components are dynamically exchangeable.

    • Andrew Z. Lin
    • Kiersten M. Ruff
    • Rohit V. Pappu
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • Sobkowiak et al., present a comprehensive genomic epidemiology of SARS-CoV-2 in Peru from 2020 to 2024, highlighting the emergence and spread of key variants including Lambda and Gamma P.1.12. The work provides valuable insights into regional viral transmission dynamics in a high-burden, middle-income setting, emphasizing the importance of sustained genomic surveillance.

    • Benjamin Sobkowiak
    • Amy Langdon
    • Pablo Tsukayama
    ResearchOpen Access
    Communications Medicine
    Volume: 6, P: 1-10

  • There is increasing evidence of a functional interaction between acute myeloid leukemia (AML) and immune cells, influencing disease outcome. Here the authors study how distinct oncogenes differentially affect the host immune response to leukemic cells in preclinical models of AML.

    • Rebecca J. Austin
    • Jasmin Straube
    • Megan J. Bywater
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • The caudal-related homeobox transcription factor CDX2 is expressed in leukemic cells in the majority of patients with leukemia but not during normal blood formation. Here, the authors report a mouse model with conditional Cdx2 expression showing de novo leukemic transformation, and use it to optimize treatment in high-risk AML.

    • Therese Vu
    • Jasmin Straube
    • Steven W. Lane
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • Mosquito biting preferences and their impact on malaria transmission are not well understood. Here, the authors report findings from a longitudinal cohort study in Western Kenya which show that males aged 5-15 years tend to be bitten the most, and infectious mosquitoes appear to be more likely to bite infected individuals.

    • Christine F. Markwalter
    • Zena Lapp
    • Wendy Prudhomme O’Meara
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-11

  • Bruedigam et al. explore the mechanism of action and therapeutic benefit of telomerase inhibitor imetelstat in a collection of PDXs from patients with AML and demonstrate that, in combination with chemotherapy, it re-sensitizes treatment-resistant AML cells.

    • Claudia Bruedigam
    • Amy H. Porter
    • Steven W. Lane
    ResearchOpen Access
    Nature Cancer
    Volume: 5, P: 47-65