Using a combination of cryo-electron microscopy, activity measurements and in vivo experiments, the authors show that decylubiquinone, an analogue of the mammalian electron carrier, ubiquinol, binds to and inhibits the CIII2CIV2 supercomplex from M. smegmatis, and inhibits growth of M. tuberculosis. This compound may thus represent a new therapeutic strategy to treat tuberculosis.
- Sylwia Król
- Terezia Kovalova
- Peter Brzezinski
