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Showing 1–10 of 10 results
Advanced filters: Author: Ana Palma Teixeira Clear advanced filters

  • In this Review, Teixeira et al. discuss emerging strategies for developing and improving engineered-cell therapies. They outline progress from ex vivo engineered autologous cells to in vivo reprogramming, advances in delivery systems and the remaining translational barriers.

    • Ana Palma Teixeira
    • Dominique Aubel
    • Martin Fussenegger
    Reviews
    Nature Reviews Genetics
    P: 1-18

  • Circadian clocks integrate external environmental and internal physiological cues to generate oscillations of secreted endocrine signals. Here the authors build a melatonin-based circadian biomarker-driven gene switch in mammalian cells for type-2 diabetes treatment by oscillatory GLP-1 release.

    • Nik Franko
    • Shichao Li
    • Martin Fussenegger
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-9

  • Petrels are wide-ranging, highly threatened seabirds that often ingest plastic. This study used tracking data for 7,137 petrels of 77 species to map global exposure risk and compare regions, species, and populations. The results show higher exposure risk for threatened species and stress the need for international cooperation to tackle marine litter.

    • Bethany L. Clark
    • Ana P. B. Carneiro
    • Maria P. Dias
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • Current synthetic gene switches face limitations including cytotoxicity and long-term side-effects. Here, authors present an aspirin-activated system, demonstrating the regulation of insulin expression in diabetic mice, restoring glucose levels, alleviating pain, and reducing biomarkers of inflammation.

    • Jinbo Huang
    • Ana Palma Teixeira
    • Martin Fussenegger
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • The authors show modular functionality of TetR-like proteins in mammalian cells, separating the protein–DNA and the protein–protein interaction. This allows for engineered ON- and OFF-type responses to stimuli, higher order and multi-input logics.

    • Adrian Bertschi
    • Pengli Wang
    • Martin Fussenegger
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 19, P: 767-777

  • Huang et al. develop an interface to allow electrode-mediated stimulation of gene expression in human cells, utilizing direct current-generated reactive oxygen species to stimulate transgene expression downstream of the KEAP1–NRF2 biosensor. In a type 1 diabetic mouse model, this interface is demonstrated to ameliorate hyperglycemia by stimulating insulin expression.

    • Jinbo Huang
    • Shuai Xue
    • Martin Fussenegger
    ResearchOpen Access
    Nature Metabolism
    Volume: 5, P: 1395-1407

  • Synthetic gene circuits can endow cells with therapeutic functions. This Review discusses synthetic macromolecular systems, encompassing transcriptional, translational and post-translational mechanisms, that conditionally regulate protein expression and activity in response to specific internal or external stimuli, and their role in enhancing the therapeutic efficacy and safety of engineered cell therapies.

    • Ana Palma Teixeira
    • Martin Fussenegger
    Reviews
    Nature Reviews Bioengineering
    Volume: 2, P: 1005-1022