Nature Search

Vulnerability to memory decline in aging revealed by a mega-analysis of structural brain change

Across 13 longitudinal studies (3,737 adults), the authors show that brain atrophy parallels memory loss, with a stronger coupling in later life. APOE ε4 increases decline, yet genetic risk does not modify the brain–memory relationship.

Didac Vidal-Piñeiro
Øystein Sørensen
Anders M. Fjell
ResearchOpen Access21 Nov 2025
Nature Communications

Volume: 16, P: 1-16
No phenotypic or genotypic evidence for a link between sleep duration and brain atrophy

Fjell et al. analysed multiple large-scale longitudinal MRI datasets and found no evidence for an association of sleep duration and brain atrophy, suggesting that normal brains promote adequate sleep.

Anders M. Fjell
Øystein Sørensen
Kristine B. Walhovd
ResearchOpen Access05 Oct 2023
Nature Human Behaviour

Volume: 7, P: 2008-2022
Reevaluating the role of education on cognitive decline and brain aging in longitudinal cohorts across 33 Western countries

In a large cross-national study, education was linked to better memory and larger brain volumes but not to slower cognitive or brain decline with age, suggesting that the association reflects early-life factors rather than neuroprotective effects in aging.

Anders M. Fjell
Ole Rogeberg
Didac Vidal-Piñeiro
Research28 Jul 2025
Nature Medicine

Volume: 31, P: 2967-2976
Individual sleep need is flexible and dynamically related to cognitive function

In this Perspective, Fjell and Walhovd argue that, to account for considerable interindividual variability in sleep need, future research must consider environmental, individual and situational factors when studying the impact of sleep on cognitive and brain health.

Anders M. Fjell
Kristine B. Walhovd
Reviews20 Feb 2024
Nature Human Behaviour

Volume: 8, P: 422-430
Brain change trajectories in healthy adults correlate with Alzheimer’s related genetic variation and memory decline across life

This study shows that among healthy adults tracked across their lives, brain atrophy rates correlate with genetic risk for Alzheimer’s and memory decline, and that degeneration in Alzheimer’s-vulnerable brain regions is a continuous phenomenon.

James M. Roe
Didac Vidal-Piñeiro
Yunpeng Wang
ResearchOpen Access17 Dec 2024
Nature Communications

Volume: 15, P: 1-19
Effects of prenatal opiate exposure on brain development – a call for attention

Kristine B. Walhovd
Vibeke Moe
Lars Smith
Correspondence01 May 2009
Nature Reviews Neuroscience

Volume: 10, P: 390
Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer’s disease

Cortical thickness is asymmetric, and cortical thinning occurs with age and in disease. Here the authors investigate if both cortices thin at the same rate or if the thicker hemisphere declines faster in aging and in Alzheimer’s disease.

James M. Roe
Didac Vidal-Piñeiro
Michael Vacher
ResearchOpen Access01 Feb 2021
Nature Communications

Volume: 12, P: 1-11
Author Correction: Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer’s disease

James M. Roe
Didac Vidal-Piñeiro
Michael Vacher
Amendments and CorrectionsOpen Access07 Feb 2022
Nature Communications

Volume: 13, P: 1
No significant association between self-reported physical activity and brain volumes in women and men from five European cohorts

Naiara Demnitz
William F. C. Baaré
Carl-Johan Boraxbekk
ResearchOpen Access30 May 2025
Scientific Reports

Volume: 15, P: 1-9
Stable hippocampal correlates of high episodic memory function across adulthood

Anders M. Fjell
Markus H. Sneve
Kristine B. Walhovd
ResearchOpen Access14 Mar 2025
Scientific Reports

Volume: 15, P: 1-12
Cellular correlates of cortical thinning throughout the lifespan

Didac Vidal-Pineiro
Nadine Parker
Anders M. Fjell
ResearchOpen Access11 Dec 2020
Scientific Reports

Volume: 10, P: 1-14
Cognitive and hippocampal changes weeks and years after memory training

Anne Cecilie Sjøli Bråthen
Øystein Sørensen
Kristine B. Walhovd
ResearchOpen Access12 May 2022
Scientific Reports

Volume: 12, P: 1-15
Brain aging differs with cognitive ability regardless of education

Kristine B. Walhovd
Lars Nyberg
Anders M. Fjell
ResearchOpen Access16 Aug 2022
Scientific Reports

Volume: 12, P: 1-12
Within-session verbal learning slope is predictive of lifespan delayed recall, hippocampal volume, and memory training benefit, and is heritable

Kristine B. Walhovd
Anne Cecilie Sjøli Bråthen
Anders M. Fjell
ResearchOpen Access03 Dec 2020
Scientific Reports

Volume: 10, P: 1-13
Circulating S100B levels at birth and risk of six major neuropsychiatric or neurological disorders: a two-sample Mendelian Randomization Study

Mengyu Pan
James M. Roe
Yunpeng Wang
ResearchOpen Access24 May 2023
Translational Psychiatry

Volume: 13, P: 1-7
Elaboration Benefits Source Memory Encoding Through Centrality Change

Inge K. Amlien
Markus H. Sneve
Anders M. Fjell
ResearchOpen Access06 Mar 2019
Scientific Reports

Volume: 9, P: 1-13

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