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Showing 1–7 of 7 results
Advanced filters: Author: Anders Wittrup Clear advanced filters

  • Lipid nanoparticles (LNPs) fate after up take by cells is important for therapies. Here, the authors report on key barriers limiting RNA delivery by LNPs, including restricted endosomal escape, ESCRT-mediated membrane repair, and separation of lipid and RNA components during endosomal sorting.

    • Johanna M. Johansson
    • Hampus Du Rietz
    • Anders Wittrup
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20

  • Endosomal escape and subsequent cytosolic delivery of siRNA therapeutics is inefficient, and quantification is difficult. Here the authors report a confocal microscopy-based method to quantify cytosolic delivery of fluorescently labelled siRNA during lipid-mediated delivery.

    • Hampus Hedlund
    • Hampus Du Rietz
    • Anders Wittrup
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • Therapeutic siRNA becomes trapped in endosomes, limiting its efficacy. Here the authors use fluorescently-tagged galectin-9 as a biosensor for membrane damage to monitor endosomal escape of cholesterol-conjugated siRNA following treatment of small molecule membrane-destabilising drugs.

    • Hampus Du Rietz
    • Hampus Hedlund
    • Anders Wittrup
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-17

  • Small interfering RNA (siRNA)-based drugs offer a promising approach to block the synthesis of disease-causing proteins, although their delivery has posed challenges. The authors review recent advances in siRNA therapeutics, including progress in overcoming delivery challenges, and clinical trials showing efficient and durable gene knockdown in the liver.

    • Anders Wittrup
    • Judy Lieberman
    Reviews
    Nature Reviews Genetics
    Volume: 16, P: 543-552