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Showing 1–50 of 183 results

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Differential p53 phosphorylation and activation of apoptosis-promoting genes Bax and Fas/APO-1 by irradiation and ara-C treatment

Tohru Kobayashi
Sanbao Ruan
Wei Zhang
Research10 Jul 1998
Cell Death & Differentiation

Volume: 5, P: 584-591
Secondary acute myeloid leukemia with inv(16): report of two cases following paclitaxel-containing chemotherapy and review of the role of intensified ara-C therapy

JF Seymour
SK Juneja
HM Prince
Research03 Nov 1999
Leukemia

Volume: 13, P: 1735-1740
Declining rates of treatment-related mortality in patients with newly diagnosed AML given ‘intense’ induction regimens: a report from SWOG and MD Anderson

M Othus
H Kantarjian
E Estey
Research13 Jun 2013
Leukemia

Volume: 28, P: 289-292
Targeting Hsp90 by 17-AAG in leukemia cells: mechanisms for synergistic and antagonistic drug combinations with arsenic trioxide and Ara-C

H Pelicano
J S Carew
P Huang
Research16 Feb 2006
Leukemia

Volume: 20, P: 610-619
Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia

Chronic lymphocytic leukaemia cells depend on glutathione to counteract their high reactive oxygen species (ROS) levels. However, their ability to synthesize this antioxidant is compromised by inefficient cystine uptake. Huang and colleagues now show that bone marrow stromal cells promote leukaemia cell survival by metabolizing cystine to cysteine and releasing it into the microenvironment to be taken up by leukaemia cells.

Wan Zhang
Dunyaporn Trachootham
Peng Huang
Research19 Feb 2012
Nature Cell Biology

Volume: 14, P: 276-286
Orthogonal proteogenomic analysis identifies the druggable PA2G4-MYC axis in 3q26 AML

The overexpression of the ecotropic viral integration site-1 gene (EVI1/MECOM) marks the most lethal acute myeloid leukemia subgroup carrying 3q26 abnormalities. Here, pan-histone deacetylase inhibitors are identified as potent repressors of EVI1 and PA2G4 as a druggable target.

Matteo Marchesini
Andrea Gherli
Giovanni Roti
ResearchOpen Access04 Jun 2024
Nature Communications

Volume: 15, P: 1-22
Low-level expression of SAMHD1 in acute myeloid leukemia (AML) blasts correlates with improved outcome upon consolidation chemotherapy with high-dose cytarabine-based regimens

George Z. Rassidakis
Nikolas Herold
Joseph D. Khoury
ResearchOpen Access19 Oct 2018
Blood Cancer Journal

Volume: 8, P: 1-10
New drugs for therapy of AML

EH Estey
Research04 Mar 2002
Leukemia

Volume: 16, P: 306-309
Nelarabine

Varsha Gandhi
Michael J. Keating
Peter Kirkpatrick
Comments & Opinion01 Jan 2006
Nature Reviews Drug Discovery

Volume: 5, P: 17-18
Treatment of newly diagnosed AML, RAEB-t or RAEB with lisofylline or placebo in addition to chemotherapy

EH Estey
PF Thall
MJ Keating
Research12 Jun 1999
Leukemia

Volume: 13, P: 850-854
The combination of hyper-CVAD plus nelarabine as frontline therapy in adult T-cell acute lymphoblastic leukemia and T-lymphoblastic lymphoma: MD Anderson Cancer Center experience

P Jain
H Kantarjian
S Faderl
Correspondence25 Oct 2013
Leukemia

Volume: 28, P: 973-975
The hyper-CVAD regimen improves outcome in relapsed acute lymphoblastic leukemia

CA Koller
HM Kantarjian
M Keating
Research01 Dec 1997
Leukemia

Volume: 11, P: 2039-2044
Histone deacetylase inhibitor targets CD123/CD47-positive cells and reverse chemoresistance phenotype in acute myeloid leukemia

Bowen Yan
Qinwei Chen
Yi Qiu
Research05 Oct 2018
Leukemia

Volume: 33, P: 931-944
Machine-learning driven strategies for adapting immunotherapy in metastatic NSCLC

The approval of first line immune checkpoint blockade (ICB) has improved outcomes for patients with metastatic non-small cell lung cancer (mNSCLC), however, whether patients would benefit more from ICB alone or alongside chemotherapy is unclear. Here, the authors develop a machine-learning based approach to help guide individual treatment selection patients with mNSCLC.

Maliazurina B. Saad
Qasem Al-Tashi
Jia Wu
ResearchOpen Access24 Jul 2025
Nature Communications

Volume: 16, P: 1-11
Long-term follow-up results of alpha-interferon-based regimens in patients with late chronic phase chronic myelogenous leukemia

S Sacchi
HM Kantarjian
M Talpaz
Research01 Oct 1997
Leukemia

Volume: 11, P: 1610-1616
SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade

mRNA vaccines targeting SARS-CoV-2 also sensitize tumours to immune checkpoint inhibitors.

Adam J. Grippin
Christiano Marconi
Steven H. Lin
ResearchOpen Access22 Oct 2025
Nature

Volume: 647, P: 488-497
Mobilization of Transduced Tetracycline Resistance by the Δ Transfer Factor in Salmonella typhimurium and S. typhi

E. S. ANDERSON
DOROTHY PERRET
Research20 May 1967
Nature

Volume: 214, P: 810-811
Expression of Bcl-2-related genes in normal and AML progenitors: changes induced by chemotherapy and retinoic acid

M Andreeff
S Jiang
S Zhao
Research03 Nov 1999
Leukemia

Volume: 13, P: 1881-1892
Dual targeting of EZH2 and EZH1 drives exit of leukemia stem cells from quiescence and potentiates chemotherapy in acute myeloid leukemia

Hiroki Akiyama
Yuki Nishida
Michael Andreeff
CorrespondenceOpen Access24 Apr 2025
Blood Cancer Journal

Volume: 15, P: 1-5
Myeloid neoplasms associated with t(3;12)(q26.2;p13) are clinically aggressive, show myelodysplasia, and frequently harbor chromosome 7 abnormalities

Arash Ronaghy
Shimin Hu
Tariq Muzzafar
Research27 Oct 2020
Modern Pathology

Volume: 34, P: 300-313
Acute promyelocytic leukemia current treatment algorithms

Musa Yilmaz
Hagop Kantarjian
Farhad Ravandi
ReviewsOpen Access30 Jun 2021
Blood Cancer Journal

Volume: 11, P: 1-9
Inhibition of DNA Synthesis but not of Poly-dAT Synthesis by the Arabinose Analogue of Cytidine in vitro

N. BURR FURLONG
CAROL GRESHAM
Correspondence13 Oct 1971
Nature New Biology

Volume: 233, P: 212-214
High-throughput in vivo mapping of RNA accessible interfaces to identify functional sRNA binding sites

Mapping RNA accessibility is valuable for identifying functional/regulatory RNA regions. Here the authors introduce INTERFACE, an intracellular method that quantifies antisense hybridization efficacy of any number of RNA regions simultaneously via a transcriptional elongation output, measurable via RNA-seq

Mia K. Mihailovic
Jorge Vazquez-Anderson
Lydia M. Contreras
ResearchOpen Access04 Oct 2018
Nature Communications

Volume: 9, P: 1-16
Inhibition of RNA transcription: a biochemical mechanism of action against chronic lymphocytic leukemia cells by fludarabine

P Huang
A Sandoval
W Plunkett
Research04 Aug 2000
Leukemia

Volume: 14, P: 1405-1413
Loss of p53 and altered miR15-a/16-1→MCL-1 pathway in CLL: insights from TCL1-Tg:p53^−/− mouse model and primary human leukemia cells

J Liu
G Chen
P Huang
Research23 Apr 2013
Leukemia

Volume: 28, P: 118-128
Efficacy and clinicogenomic correlates of response to immune checkpoint inhibitors alone or with chemotherapy in non-small cell lung cancer

Immune checkpoint inhibitors with or without chemotherapy are now standard of care for non-small cell lung cancer. However, the benefits of combination vs sequential therapy have not been fully explored. Here, the authors analysed 1,133 patient records and show combination therapy showed increased protection against early progression, but similar overall survival.

Lingzhi Hong
Muhammad Aminu
Natalie I. Vokes
ResearchOpen Access08 Feb 2023
Nature Communications

Volume: 14, P: 1-15
Neoadjuvant chemotherapy plus nivolumab with or without ipilimumab in operable non-small cell lung cancer: the phase 2 platform NEOSTAR trial

The combination of neoadjuvant nivolumab, ipilimumab and chemotherapy showed promising efficacy in patients with resectable non-small cell lung cancer, with higher tumor immune cell infiltration and tertiary lymphoid structures after treatment compared with neoadjuvant nivolumab plus chemotherapy.

Tina Cascone
Cheuk H. Leung
Boris Sepesi
ResearchOpen Access16 Mar 2023
Nature Medicine

Volume: 29, P: 593-604
C1q drives neural stem cell quiescence by regulating cell cycle and metabolism through BAI1

The authors uncover a direct, BAI1-dependent, role for C1q in the control of neural stem cell proliferation and quiescence via MDM2–p53 and p32, a complement cascade-independent mechanism of C1q action that has implications for central nervous system health and disease.

Katja M. Piltti
Anita Lakatos
Aileen J. Anderson
ResearchOpen Access11 Dec 2025
Nature Communications

Volume: 16, P: 1-18
Enhancing NSCLC recurrence prediction with PET/CT habitat imaging, ctDNA, and integrative radiogenomics-blood insights

Predicting recurrence risk in non small cell lung cancer can help to guide treatment decisions. Here, the authors use CT and PET imaging to develop predictive imaging subtypes, which can be integrated with existing ctDNA methods to predict recurrence.

Sheeba J. Sujit
Muhammad Aminu
Jia Wu
ResearchOpen Access11 Apr 2024
Nature Communications

Volume: 15, P: 1-14
A quantitative analysis of heterogeneities and hallmarks in acute myelogenous leukaemia

An analysis of a proteomics database of leukaemia cell lines and samples from patients with acute myelogenous leukaemia uncovers heterogeneity in protein expression as well as proteomic hallmarks and signatures for patient stratification.

C. W. Hu
Y. Qiu
S. M. Kornblau
Research15 Apr 2019
Nature Biomedical Engineering

Volume: 3, P: 889-901
Autoantibodies as predictive tools in systemic sclerosis

Autoantibodies—predominantly antinuclear antibodies—are strong predictors of disease outcome and the pattern of organ complications in patients with systemic sclerosis (SSc). In conjunction with improved methods to detect and evaluate autoantibodies, this strong association offers a real chance for risk stratification and disease assessment in patients with SSc.

Svetlana I. Nihtyanova
Christopher P. Denton
Reviews01 Feb 2010
Nature Reviews Rheumatology

Volume: 6, P: 112-116
Neoadjuvant nivolumab or nivolumab plus ipilimumab in operable non-small cell lung cancer: the phase 2 randomized NEOSTAR trial

Neoadjuvant treatment with nivolumab plus ipilimumab is well tolerated and demonstrates clinical efficacy in patients with early stage lung cancer.

Tina Cascone
William N. William Jr
Boris Sepesi
Research18 Feb 2021
Nature Medicine

Volume: 27, P: 504-514
An anatomic gene expression atlas of the adult mouse brain

This resource article describes a bioinformatical tool that, accessing an extensive gene expression database, allows the definition and identification of new brain structures based on gene expression patterns.

Lydia Ng
Amy Bernard
Michael Hawrylycz
Research15 Feb 2009
Nature Neuroscience

Volume: 12, P: 356-362
A phase I study of a 24 hour infusion of gemcitabine in previously untreated patients with inoperable non-small-cell lung cancer

H Anderson
N Thatcher
H Hansen
Research01 Aug 1996
British Journal of Cancer

Volume: 74, P: 460-462
Chemotherapy only compared to chemotherapy followed by transplantation in high risk myelodysplastic syndrome and secondary acute myeloid leukemia; two parallel studies adjusted for various prognostic factors

M Oosterveld
P Muus
E Estey
Research30 Aug 2002
Leukemia

Volume: 16, P: 1615-1621
MRx102, a triptolide derivative, has potent antileukemic activity in vitro and in a murine model of AML

B Z Carter
D H Mak
M Andreeff
Research09 Sept 2011
Leukemia

Volume: 26, P: 443-450
751 TREATMENT OF STREPTOCOCCAL PHARYNGITIS WITH B.I.D. CEPHALEXIN

D C Anderson
S Hollister
A Ellison
Research01 Apr 1978
Pediatric Research

Volume: 12, P: 489
Synergistic effect of targeting mTOR by rapamycin and depleting ATP by inhibition of glycolysis in lymphoma and leukemia cells

R-H Xu
H Pelicano
P Huang
Research29 Sept 2005
Leukemia

Volume: 19, P: 2153-2158
Multi-region exome sequencing reveals genomic evolution from preneoplasia to lung adenocarcinoma

There has been a drastic increase in detection of lung nodules, many of which are precancers, preinvasive, minimally invasive or sometimes invasive lung cancers. Here, Hu et al. perform multi-region exome sequencing to discern the evolutional trajectory from precancers to invasive lung cancers.

Xin Hu
Junya Fujimoto
Jianjun Zhang
ResearchOpen Access05 Jul 2019
Nature Communications

Volume: 10, P: 1-10
Comprehensive T cell repertoire characterization of non-small cell lung cancer

Relevant features of T cell repertoire in human cancer remain to be delineated. Here the authors show, by TCR sequencing in a large cohort of lung cancer patients, that while a majority of T cell clones are shared between tumor and adjacent lung tissue, less frequent tumor-unique T cell clones correlate with worse prognosis.

Alexandre Reuben
Jiexin Zhang
Jianjun Zhang
ResearchOpen Access30 Jan 2020
Nature Communications

Volume: 11, P: 1-13
A STAT3 degrader demonstrates efficacy in venetoclax resistant acute myeloid leukemia

Samarpana Chakraborty
Claudia Morganti
Aditi Shastri
ResearchOpen Access17 Feb 2026
Leukemia

P: 1-13
Immune evolution from preneoplasia to invasive lung adenocarcinomas and underlying molecular features

The evolution of immune landscape in lung adenocarcinoma (ADC) is largely unknown. Here the authors use a cohort of resected invasive lung ADC and its precursors and show a gradual increase of immunosuppression and decrease of anti-tumor response associated with specific genomic and epigenetic features.

Hitoshi Dejima
Xin Hu
Jianjun Zhang
ResearchOpen Access11 May 2021
Nature Communications

Volume: 12, P: 1-11
Overexpression of Bax gene sensitizes K562 erythroleukemia cells to apoptosis induced by selective chemotherapeutic agents

Tohru Kobayashi
Sanbao Ruan
Wei Zhang
Research01 Apr 1998
Oncogene

Volume: 16, P: 1587-1591
Nodal immune flare mimics nodal disease progression following neoadjuvant immune checkpoint inhibitors in non-small cell lung cancer

Granulomatous/sarcoid-like lesions have been reported in patients treated with immune checkpoint inhibitors (ICIs). Here the authors report the occurrence of “nodal immune flare”, an apparent radiological cancer progression in the nodes characterized by the absence of cancer and the presence of non-caseating granulomas, in patients with non-small cell lung cancer following neoadjuvant ICI treatment.

Tina Cascone
Annikka Weissferdt
Boris Sepesi
ResearchOpen Access19 Aug 2021
Nature Communications

Volume: 12, P: 1-15
Evolution of DNA methylome from precancerous lesions to invasive lung adenocarcinomas

It is known that invasive lung adenocarcinomas evolve from pre-cancerous dysplastic lesions. In this study, the authors show that evolution of pre-cancerous lesions is accompanied by DNA methylation alterations, and that global hypomethylation correlates with immune infiltration, mutational burden and copy number alterations.

Xin Hu
Marcos R. Estecio
Jianjun Zhang
ResearchOpen Access29 Jan 2021
Nature Communications

Volume: 12, P: 1-13
Private benefit of β-lactamase dictates selection dynamics of combination antibiotic treatment

The authors derive a criterion for when β-lactam/β-lactamase inhibitor combinations can select against a β-lactam-resistant bacterial strain. In particular, the private benefit of resistance is shown to be estimable from clonal growth curves and predictive of selection outcomes.

Helena R. Ma
Helen Z. Xu
Lingchong You
ResearchOpen Access27 Sept 2024
Nature Communications

Volume: 15, P: 1-14
Sorafenib induces apoptosis of AML cells via Bim-mediated activation of the intrinsic apoptotic pathway

W Zhang
M Konopleva
M Andreeff
Research17 Jan 2008
Leukemia

Volume: 22, P: 808-818
Ink4a and Arf are crucial factors in the determination of the cell of origin and the therapeutic sensitivity of Myc-induced mouse lymphoid tumor

E Sugihara
T Shimizu
H Saya
Research10 Oct 2011
Oncogene

Volume: 31, P: 2849-2861
Stromal cells prevent apoptosis of AML cells by up-regulation of anti-apoptotic proteins

M Konopleva
S Konoplev
M Andreeff
Research30 Aug 2002
Leukemia

Volume: 16, P: 1713-1724
Long term impacts of early social environment on chimpanzee white matter

Michele M. Mulholland
Erin Hecht
William D. Hopkins
ResearchOpen Access02 Dec 2024
Scientific Reports

Volume: 14, P: 1-8

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